Behavior of sphingomyelin and ceramide in a tear film lipid layer model
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27837653
DOI
10.1016/j.aanat.2016.10.005
PII: S0940-9602(16)30183-2
Knihovny.cz E-zdroje
- Klíčová slova
- Ceramide, Langmuir balance, Molecular dynamics simulations, Sphingomyelin, Tear film lipid layer,
- MeSH
- ceramidy chemie MeSH
- estery cholesterolu chemie MeSH
- lidé MeSH
- lipidy chemie MeSH
- meibomské žlázky chemie metabolismus MeSH
- povrchové napětí MeSH
- sfingomyeliny chemie MeSH
- simulace molekulární dynamiky MeSH
- slzy chemie MeSH
- termodynamika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ceramidy MeSH
- estery cholesterolu MeSH
- lipidy MeSH
- sfingomyeliny MeSH
Tear film lipid layer is a complex lipid mixture forming the outermost interface between eye and environment. Its key characteristics, such as surface tension and structural stability, are governed by the presence of polar lipids. The origin of these lipids and exact composition of the mixture are still elusive. We focus on two minor polar lipid components of the tear film lipid later: sphingomyelin and ceramide. By employing coarse grain molecular dynamics in silico simulations accompanied by Langmuir balance experiments we provide molecular-level insight into behavior of these two lipids in a tear film lipid layer model. Sphingomyelin headgroups are significantly exposed at the water-lipids boundary while ceramide molecules are incorporated between other lipids frequently interacting with nonpolar lipids. Even though these two lipids increase surface tension of the film, their molecular-level behavior suggests that they have a stabilizing effect on the tear film lipid layer.
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