Tissue ischemia worsens during hemodialysis in end-stage renal disease patients
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
27886367
DOI
10.5301/jva.5000630
PII: F5F9D220-C849-40F9-8EA2-FFE8E5F24F57
Knihovny.cz E-resources
- MeSH
- Biomarkers blood MeSH
- Time Factors MeSH
- Frontal Lobe blood supply MeSH
- Kidney Failure, Chronic diagnosis therapy MeSH
- Renal Dialysis adverse effects MeSH
- Adult MeSH
- Brain Ischemia diagnosis etiology physiopathology MeSH
- Ischemia diagnosis etiology physiopathology MeSH
- Cognition Disorders etiology physiopathology psychology MeSH
- Oxygen blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Cerebrovascular Circulation MeSH
- Pilot Projects MeSH
- Regional Blood Flow MeSH
- Risk Factors MeSH
- Hand blood supply MeSH
- Blood Flow Velocity MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- Oxygen MeSH
BACKGROUND: Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was to describe brain and hand oxygenation values in ESRD patients and their changes during hemodialysis. METHODS: Twenty-seven patients treated by chronic hemodialysis and 17 controls patients of the same age were included in the study. Regional saturation of oxygen (SrO2) was measured at the brain frontal lobe and at the hand with dialysis access using the INVOS 5100C. In 17 of ESRD patients, SrO2 was also monitored throughout hemodialysis. Finger systolic blood pressure and basic hemodialysis and laboratory data were collected. RESULTS: Dialysis patients had lower brain and also hand SrO2 values at rest (51.5 ± 10.9 vs. 68 ± 7%, p<0.0001 and 55 ± 16 vs. 66 ± 8%, p = 0.03, respectively). Both values further decreased during the first 35 minutes of hemodialysis (brain SrO2 to 47 ± 8%, p<0.0001 and hand to 45 ± 14%, p<0.0001, respectively). The brain SrO2 decrease was related to the ultrafiltration rate, the hand SrO2 decrease to the finger pressure and to blood hemoglobin. CONCLUSIONS: Chronic dialysis patients suffer from tissue ischemia and that even worsens after the beginning of hemodialysis. This observation may contribute to the understanding of cognitive deficit etiology.
References provided by Crossref.org
The effect of high-flow arteriovenous fistulas on systemic haemodynamics and brain oxygenation
Review of the structural and functional brain changes associated with chronic kidney disease
