New adenoviruses from new primate hosts - growing diversity reveals taxonomic weak points
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27894993
DOI
10.1016/j.ympev.2016.11.013
PII: S1055-7903(16)30374-8
Knihovny.cz E-zdroje
- Klíčová slova
- Adenovirus, Phylogeny, Primate, Taxonomy,
- MeSH
- Bayesova věta MeSH
- fylogeneze MeSH
- genetická variace * MeSH
- interakce hostitele a patogenu * MeSH
- lidé MeSH
- nukleotidy genetika MeSH
- opičí adenoviry klasifikace genetika MeSH
- primáti virologie MeSH
- sekvence nukleotidů MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- nukleotidy MeSH
The knowledge of the closest human relatives of human adenoviruses (AdVs) such as adenoviruses found in nonhuman primates is still limited, despite the growing importance of adenoviruses in vaccine development, gene and cancer therapy. We examined 153 stool samples of 17 non-human primate species and detected adenoviral DNA sequences of DNA polymerase (DPOL) gene in 54 samples (35%), originating from 12 out of 17 primate species. We further sequenced 15 hexon gene fragments and based on the phylogenetic analysis we propose two new provisional species SAdV-H and SAdV-I. Our study shows extensive diversity of adenoviral strains forming separate clades often from closely related host species from old world monkeys suggesting the existence of new species of AdVs and shows the necessity for clear ICTV guidelines for final establishment of so far provisional AdV species.
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