Can Leukocyte Telomere Length Predict Survival Time in Heart Transplant Recipients over a Minimal Follow-Up of 20 years?
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
27978413
DOI
10.14712/fb2016062050188
PII: file/5819/fb2016a0023.pdf
Knihovny.cz E-resources
- MeSH
- Survival Analysis MeSH
- Adult MeSH
- Telomere Homeostasis * MeSH
- Kaplan-Meier Estimate MeSH
- Leukocytes metabolism MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Cause of Death MeSH
- Heart Failure etiology mortality MeSH
- Heart Transplantation mortality MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
In humans, leukocyte telomere length (LTL) reduces with age and is reported to be inversely associated with ageing-related diseases. We measured LTL in leukocyte DNA using a quantitative PCR-based method from 127 blood samples of heart recipients (107 males, 20 females, age 44.1 ± 10.5), followed for up to 30 years. Patients with coronary artery disease survived for a shorter time and also had shorter LTL (both P < 0.05 after adjustment for age and sex) than subjects with dilated cardiomyopathy. Patients with non-cardiac causes of death had shorter LTL than patients with cardiac causes (P < 0.05 after adjustment for age). An inverse correlation between LTL and age (P < 0.03) was observed in patients with non-cardiac causes of death only. Most importantly, LTL was not associated with general survival time in patients after heart transplantation. However, shorter LTL was a marker of non-cardiac causes of death. Different LTLs and survival times were determined in association with aetiology of heart failure (HF).
Cardiology Centre Institute for Clinical and Experimental Medicine Prague Czech Republic
Medical Statistical Unit Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides
