Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
- MeSH
- beta blokátory farmakologie MeSH
- glukosa metabolismus MeSH
- glykolýza MeSH
- ischemie farmakoterapie metabolismus MeSH
- kyselina dichloroctová farmakologie MeSH
- lidé MeSH
- nádory farmakoterapie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- beta blokátory MeSH
- glukosa MeSH
- kyselina dichloroctová MeSH
The Warburg effect states that the main source of energy for cancer cells is not aerobic respiration, but glycolysis-even in normoxia. The shift from one to the other is governed by mutually counteracting enzymes: pyruvate dehydrogenase and pyruvate dehydrogenase kinase (PDK). Anaerobic metabolism of cancer cells promotes cell proliferation, local tissue immunosuppression, resistance to hypoxic conditions, and metastatic processes. By switching glucose back to oxidative metabolism, these effects might be reversed. This can be achieved using PDK inhibitors, such as dichloroacetate. Patients suffering from ischemic conditions might benefit from this effect. On the other hand, the β-blockers (adrenergic β-antagonists) often used in these patients appear to improve cancer-specific survival, and nonselective β-blockers have been shown to promote glucose oxidation. Might there be a link?
b Medical Faculty University of Ljubljana Ljubljana Slovenia
e Weill Cornell Medicine in Qatar Qatar Foundation Education City Doha Qatar
Citace poskytuje Crossref.org
