BACKGROUND: The idea of latent social skills in autism emerged as a possible interpretation of the rapid (but temporary) improvement of autistic subjects in oxytocin studies. We tested a hypothesis that a normal response to Item No 59 "Secure Base" from the third version of the Autism Diagnostic Interview - Revised (ADIR-59) could indicate the presence of latent social skills in autism. METHODS: We examined 110 autistic children (88 boys and 22 girls) with a mean age of 6.0±2.5 years (range: 2.2-14.8 years) using the Autism Diagnostic Observation Schedule (ADOS) - Generic. A diagnosis of mental retardation was established in 68 autistic children (62%). RESULTS: The difference in the ADOS social domain between children aged ≤5 years on one side and children older than 5 years on the other side was significant in subjects with normal responses to ADIR-59 (9.60 vs 6.47; P=0.031) but not in those with abnormal responses to ADIR-59 (10.62 vs 9.63; P=0.537). In a predictive model, lower ADOS social domain scores were predicted by older age (P=0.001), lower scores on the ADIR-59 (P=0.01), and the absence of mental retardation (P=0.049). CONCLUSION: The results support the hypothesis that the normal response to item ADIR-59 "Secure Base" indicates the presence of latent social skills in autism that might foretell further social growth in older autistic subjects.

Department of Child Psychiatry Charles University 2nd Faculty of Medicine and University Hospital Motol Prague

Institute of Psychology Academy of Sciences Brno Czech Republic

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American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Arlington, VA: American Psychiatric Publishing; 2013.

World Health Organization . International Classification of Diseases. 10th. Geneva: WHO; 1992.

Hollander E, Bartz J, Chaplin W, et al. Oxytocin increases retention of social cognition in autism. Biol Psychiatry. 2007;61(4):498–503. PubMed

Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A. 2010;107(9):4389–4394. PubMed PMC

Guastella A, Einfeld SL, Gray KM, et al. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol Psychiatry. 2010;67(7):692–694. PubMed

Anagnostou E, Soorya L, Chaplin W, et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial. Mol Autism. 2010;3(1):16. PubMed PMC

Watanabe T, Kuroda M, Kuwabara H, et al. Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. Brain. 2015;138(pt 11):3400–3412. PubMed

Dadds MR, MacDonald E, Cauchi A, Williams K, Levy F, Brennan J. Nasal oxytocin for social deficits in childhood autism: a randomized controlled trial. J Autism Dev Disord. 2014;44(3):521–531. PubMed

Guastella AJ, Gray KM, Rinehart NJ, et al. The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial. J Child Psychol Psychiatry. 2015;56(4):444–452. PubMed

Hrdlicka M, Dudova I. Controversies in autism: is a broader model of social disorders needed? Child Adolesc Psychiatry Ment Health. 2013;7(1):9. PubMed PMC

Klin A, Saulnier C, Tsatsanis K, Volkmar FR. Clinical evaluation in autism spectrum disorders: psychological assessment within a trans-disciplinary framework. In: Volkmar FR, Paul R, Klin A, Cohen D, editors. Handbook of Autism and Pervasive Developmental Disorders. 3rd. New York: John Wiley & Sons; 2005. pp. 772–798.

Baron-Cohen S, Leslie AM, Frith U. Does the autistic child have a “theory of mind”? Cognition. 1985;21(1):37–46. PubMed

Lord C, Rutter M, LeCouteur A. Autism diagnostic interview – revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24(5):659–685. PubMed

Rutter M, LeCouteur A, Lord C. ADI-R: The Autism Diagnostic Interview-Revised. Los Angeles, CA: Western Psychological Services; 2003.

Lord C, Risi S, Lambrecht L, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30(3):205–223. PubMed

Kim SH, Lord C. Combining information from multiple sources for the diagnosis of autism spectrum disorders for toddlers and young preschoolers from 12 to 47 months of age. J Child Psychol Psychiatry. 2012;53(2):143–151. PubMed PMC

R Core Team [homepage on the Internet] R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2015. [Accessed October 21, 2016]. Available from: http://www.R-project.org/

Revelle W [webpage on the Internet] Psych: Procedures for Personality and Psychological Research. Version = 1.5.6. Evanston, IL: Northwestern University; 2015. [Accessed October 21, 2016]. Available from: http://CRAN.R-project.org/package=psych.

Baghdadli A, Assouline B, Sonie S, et al. Developmental trajectories of adaptive behaviors from early childhood to adolescence in a cohort of 152 children. J Autism Dev Disord. 2012;42(7):1314–1325. PubMed

Fountain C, Winter AS, Bearman PS. Six developmental trajectories characterize children with autism. Pediatrics. 2012;129(5):e1112–e1120. PubMed PMC

Smith LE, Maenner MJ, Seltzer MM. Developmental trajectories in adolescents and adults with autism: the case of daily living skills. J Am Acad Child Adolesc Psychiatry. 2012;51(6):622–631. PubMed PMC

Hedvall A, Westerlund J, Fernell E, et al. Preschoolers with autism spectrum disorder followed for 2 years: those who gained and those who lost the most in terms of adaptive functioning outcome. J Autism Dev Disord. 2015;45(11):3624–3633. PubMed

Volkmar FR, Lord C, Klin A, Schultz R, Cook EH. Autism and the pervasive developmental disorders. In: Martin A, Volkmar FR, editors. Lewis´s Child and Adolescent Psychiatry: A Comprehensive Textbook. 4th. Philadelphia: Lippincott Williams & Wilkins; 2007. pp. 384–400.

Charman T. Development from preschool through school age. In: Amaral DG, Dawson G, Geschwind DH, editors. Autism Spectrum Disorders. New York: Oxford University Press; 2011. pp. 229–240.

Steensel FJA, van Bogels SM, Perrin S. Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clin Child Fam Psychol Rev. 2011;14(3):302–317. PubMed PMC

Steensel FJA, van Bogels SM, Wood JJ. Autism spectrum traits in children with anxiety disorders. J Autism Dev Disord. 2013;43(2):361–370. PubMed PMC

Ung D, Wood JJ, Ehrenreich-May J, et al. Clinical characteristics of high-functioning youth with autism spectrum disorders and anxiety. Neuropsychiatry (London) 2013;3(2) doi: 10.2217/npy.13.9. PubMed DOI PMC

Renno P, Wood JJ. Discriminant and convergent validity of the anxiety construct in children with autism spectrum disorders. J Autism Dev Disord. 2013;43(9):2135–2146. PubMed PMC

Sodian B, Frith U. Deception and sabotage in autistic, retarded and normal children. J Child Psychol Psychiatry. 1992;33(3):591–605. PubMed

Walsh P, Elsabbagh M, Bolton P, Singh I. In search of biomarkers for autism: scientific, social and ethical challenges. Nat Rev Neurosci. 2011;12(10):603–612. PubMed

Braida D, Guerini FR, Ponzoni L, et al. Association between SNAP-25 gene polymorphisms and cognition in autism: functional consequences and potential therapeutic strategies. Transl Psychiatry. 2015;5:e500. PubMed PMC

Guerini FR, Bolognesi E, Chiappedi M, et al. HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study. J Neuroimmunol. 2011;230(1–2):135–142. PubMed

Saresella M, Piancone F, Marventano I, et al. Multiple inflammasome complexes are activated in autistic spectrum disorders. Brain Behav Immun. 2016;57:125–133. PubMed