A review on acridinylthioureas and its derivatives: biological and cytotoxic activity
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review
PubMed
28370171
DOI
10.1002/jat.3464
Knihovny.cz E-resources
- Keywords
- Acridine, cytotoxicity, fluorescence, intercalation, isothiocyanate, platinum thioureas, synthesis, thiourea, urea,
- MeSH
- Acridines chemical synthesis pharmacology MeSH
- Isothiocyanates chemical synthesis pharmacology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- DNA Damage drug effects MeSH
- Proflavine chemical synthesis pharmacology MeSH
- Antineoplastic Agents chemical synthesis pharmacology MeSH
- Thiourea chemical synthesis pharmacology MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Acridines MeSH
- Isothiocyanates MeSH
- Proflavine MeSH
- Antineoplastic Agents MeSH
- Thiourea MeSH
Acridines possess two characteristics that have led many researchers to consider the agents interesting targets for future development as potential farmacophores: the planar acridine skeleton, which is able to intercalate into DNA, and the intense fluorescence of the agents. This review offers a study of the multifunctional character of acridines and the synthesis of novel acridine derivatives, with particular focus being placed on isothiocyanates and their congeners, e.g. thioureas, isothioureas, quaternary ammonium salts and platinum/gold conjugates. The review provides an overview of the structure, spectral properties, DNA binding and biological activity of acridinylthiourea congeners. These acridinylthiourea derivatives display significant cytotoxic activities against different types of cancer cell lines at micromolar concentrations. Copyright © 2017 John Wiley & Sons, Ltd.
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