Gelatinases A and B and Antioxidant Enzyme Activity in the Early Phase of Acute Myocardial Infarction
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
28374671
DOI
10.14712/fb2017063010020
PII: file/5833/fb2017a0004.pdf
Knihovny.cz E-zdroje
- MeSH
- antioxidancia metabolismus MeSH
- dusičnany krev MeSH
- dusitany krev MeSH
- glutathionperoxidasa krev MeSH
- glutathionreduktasa krev MeSH
- infarkt myokardu krev enzymologie MeSH
- katalasa krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- protein - isoformy krev MeSH
- referenční standardy MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- superoxiddismutasa MeSH
- xanthinoxidasa krev MeSH
- želatinasy krev metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antioxidancia MeSH
- dusičnany MeSH
- dusitany MeSH
- glutathionperoxidasa MeSH
- glutathionreduktasa MeSH
- katalasa MeSH
- protein - isoformy MeSH
- superoxiddismutasa MeSH
- xanthinoxidasa MeSH
- želatinasy MeSH
Oxidative stress plays important roles in the pathophysiology of acute myocardial infarction (AMI). The aim of this study was to investigate the correlation of the oxidative stress status and matrix metalloproteinase activity in AMI patients in comparison to controls. This study included 136 subjects: 68 patients with AMI (42 males/26 females; mean age 58.5 ± 10.5 years) and 68 controls (37 males/29 females; mean age 60.2 ± 12.4 years). Gelatinases A and B were assayed using gelatin zymography, enzyme activities were obtained spectrophotometrically. Gelatinase A and B activities were increased in the AMI patients' group compared to the control. Activities of serum superoxide dismutase (SOD) and xanthine oxidase (XO) were significantly higher in AMI patients (106.53 ± 23.45 U/l, P < 0.001 and 158.18 ± 29.59 U/l, P < 0.001) than in the control group (55.99 ± 10.79 U/l and 79.81 ± 7.93 U/l). The activity of catalase (CAT) in the sera of AMI patients was lower (271.31 ± 7.53 U/l, P < 0.005) than in the control group (305.94 ± 97.28 U/l). Plasma glutathione peroxidase (GPx) and glutathione reductase (GR) in AMI patients were significantly higher (582.47 ± 184.81 U/l, P < 0.001 and 59.64 ± 21.88 U/l, P < 0.001) than in the control group (275.32 ± 104.69 U/l and 47.71 ± 20.05 U/l). The present findings demonstrate activation of gelatinases A and B and oxidative stress markers in the early stage of AMI. Gelatinases, detected at high levels in AMI patients only, indicate their noticeable predisposition for becoming additional biomarkers of the early phase of AMI.
Institute for Biochemistry Faculty of Medicine University of Nis Nis Serbia
Institute for Chemistry in Medicine Faculty of Medicine University of Belgrade Belgrade Serbia
Institute for Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia
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