Diabetes mellitus 2. typu a chronická obličková choroba
[Type 2 diabetes mellitus and chronic kidney disease]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
28379021
PII: 60685
- MeSH
- Albuminuria diagnosis drug therapy etiology genetics MeSH
- Angiotensin Receptor Antagonists therapeutic use MeSH
- Antihypertensive Agents therapeutic use MeSH
- Biopsy MeSH
- Renal Insufficiency, Chronic diagnosis drug therapy etiology genetics MeSH
- Diabetes Mellitus, Type 2 complications diagnosis drug therapy MeSH
- Diabetic Nephropathies diagnosis drug therapy etiology genetics MeSH
- Genomics MeSH
- Glomerular Filtration Rate MeSH
- Angiotensin-Converting Enzyme Inhibitors therapeutic use MeSH
- Kidney diagnostic imaging pathology MeSH
- Humans MeSH
- MicroRNAs MeSH
- Ophthalmoscopy MeSH
- Proteomics MeSH
- Ultrasonography MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Angiotensin Receptor Antagonists MeSH
- Antihypertensive Agents MeSH
- Angiotensin-Converting Enzyme Inhibitors MeSH
- MicroRNAs MeSH
The number of type 2 diabetic patients is increasing world-wide and a prediction of prevalence of chronic kidney disease up to 2025 in European diabetic population is alarming. Albuminuria and estimated glomerular filtration rate are cardinal biochemical parameters in diagnostics of diabetic nephropathy. Following diagnostic methods are also used: renal ultrasonography, ophthalmoscopy and in not clarified cases renal biopsy. Long-term optimal glycemic control, efficient antihypertensive treatment by angiotensin converting enzyme inhibitor, or angiotensin receptor blocker and recommended protein intake is a cornerstone of therapy. The research is presently focused on new pathophysiological mechanisms, as analysis of genome, microRNA, kidney injury biomarkers and proteomes.Key words: chronic kidney disease - type 2 diabetes mellitus.
