Deoxyribonuclease activity in plasma of pregnant women and experimental animals
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Fetal DNA, animal model, deoxyribonuclease, preeclampsia, pregnancy complications,
- MeSH
- Biomarkers blood MeSH
- Humans MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Fetus metabolism MeSH
- Rats, Wistar MeSH
- Pre-Eclampsia blood MeSH
- Pregnancy blood MeSH
- Cell-Free Nucleic Acids blood MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Pregnancy blood MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- Cell-Free Nucleic Acids MeSH
Clinical observations and animal experiments have shown that higher fetal DNA in maternal plasma could participate on the pathogenesis of preeclampsia. The understudied factor that could participate in interindividual variability in cell-free DNA is enzymatic activity of deoxyribonuclease (DNase). We have found that healthy pregnant animals have higher plasma DNase activity than healthy pregnant women. Injection of cell-free fetal DNA into pregnant animals had no effect on DNase activity. Interspecies differences in DNase activity should be considered in animal experiments focusing on the role of fetal DNA in preeclampsia and cell-free DNA in other disease models.
Biomedical Research Center University Hospital Hradec Králové Czech Republic
e Institute of Pathophysiology Faculty of Medicine Comenius University Bratislava Slovakia
Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia
References provided by Crossref.org
Sex Difference in Plasma Deoxyribonuclease Activity in Rats
