Deoxyribonuclease activity in plasma of pregnant women and experimental animals
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Fetal DNA, animal model, deoxyribonuclease, preeclampsia, pregnancy complications,
- MeSH
- biologické markery krev MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední C57BL MeSH
- plod metabolismus MeSH
- potkani Wistar MeSH
- preeklampsie krev MeSH
- těhotenství krev MeSH
- volné cirkulující nukleové kyseliny krev MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- těhotenství krev MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- volné cirkulující nukleové kyseliny MeSH
Clinical observations and animal experiments have shown that higher fetal DNA in maternal plasma could participate on the pathogenesis of preeclampsia. The understudied factor that could participate in interindividual variability in cell-free DNA is enzymatic activity of deoxyribonuclease (DNase). We have found that healthy pregnant animals have higher plasma DNase activity than healthy pregnant women. Injection of cell-free fetal DNA into pregnant animals had no effect on DNase activity. Interspecies differences in DNase activity should be considered in animal experiments focusing on the role of fetal DNA in preeclampsia and cell-free DNA in other disease models.
Biomedical Research Center University Hospital Hradec Králové Czech Republic
e Institute of Pathophysiology Faculty of Medicine Comenius University Bratislava Slovakia
Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia
Citace poskytuje Crossref.org
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