The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability. The NewProt portal is freely accessible at http://newprot.cmbi.umcn.nl/ and http://newprot.fluidops.net/.

Bio Prodict B 5 NieuweMarktstraat 54e 6511 AA Nijmegen The Netherlands

CMBI Radboud University Medical Centre Geert Grooteplein Zuid 26 28 6525 GA Nijmegen The Netherlands

Department of Biotechnology and Enzyme Catalysis Institute of Biochemistry University of Greifswald Felix Hausdorff Str 4 17487 Greifswald Germany

Enantis INBIT Kamenice 34 625 00 Brno Czech Republic

Fluid Operations AG Altrottstraße 31 69190 Walldorf Germany

Fluid Operations AG Walldorf Germany

Loschimidt Laboratories Department of Experimental Biology and RECETOX Faculty of Science Masaryk University Kamenice 5 A13 625 00 BRNO Czech Republic

Metaphacts GmbH Daimlerstraße 36 69190 Walldorf Germany

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