Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- NAMPT, PBEF, Visfatin, preterm birth, preterm premature rupture of membranes,
- MeSH
- Cytokines blood genetics MeSH
- Adult MeSH
- Fetal Blood chemistry MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Humans MeSH
- Nicotinamide Phosphoribosyltransferase blood genetics MeSH
- Fetal Membranes, Premature Rupture blood genetics MeSH
- Premature Birth blood genetics MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cytokines MeSH
- nicotinamide phosphoribosyltransferase, human MeSH Browser
- Nicotinamide Phosphoribosyltransferase MeSH
OBJECTIVES: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs). METHODS: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM). RESULTS: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p = .021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p = .027; p = .039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p = .007). CONCLUSIONS: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.
b Research Centre for the Toxic Compounds in the Environment Brno Czech Republic
c Department of Biochemistry Faculty of Medicine Masaryk University Brno Czech Republic
Department of Obstetrics and Gynaecology University Hospital Brno Brno Czech Republic
Department of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
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