Discussions of the survival determinism concept have previously focused on its primary role in the evolution of early unicellular organisms in the light of findings which have been reported on a number of diseases. The rationale for such parallel was in the view according to which multicellular organisms could be regarded as sophisticated colonies of semi-autonomous, single-celled entities, whereby various diseases were described as conditions arising upon the activation of the respective survival mechanisms in a milieu unsuitable for such robust stress response. The cellular mechanisms that were discussed in these contexts have been known to play various roles in other biological processes. The proposed notion could thereby be further extended to discussion on mechanisms for the implementation of the respective survival pathways in the development of metazoa, considering that they would have been propagated in their evolution for so long. This manuscript first presents a concise overview of the model previously discussed, followed by the discussion on the role of respective mechanism(s) in origins and development of metazoa. Finally, a reflection on the concept in relation to the prominent evolutionary models is put forward to illustrate a broader context of what is being discussed.

Institute of Pathological Physiology 1st Faculty of Medicine Charles University U Nemocnice 5 128 53 Praha 2 Czech Republic

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Med Hypotheses. 2011 Sep;77(3):389-400 PubMed

Proc Natl Acad Sci U S A. 1984 Dec;81(24):8009-13 PubMed

Nat Rev Cancer. 2006 Dec;6(12):924-35 PubMed

Dev Cell. 2004 Sep;7(3):313-25 PubMed

Genetics. 1991 Mar;127(3):463-73 PubMed

Cancer Res. 2008 Oct 1;68(19):8146-55 PubMed

Nature. 1975 May 15;255(5505):197-200 PubMed

Brain Pathol. 2009 Jul;19(3):483-92 PubMed

Biochim Biophys Acta. 2013 Feb;1830(2):2385-94 PubMed

Science. 2007 Jan 26;315(5811):518-21 PubMed

Genes Dev. 2009 Jun 1;23(11):1303-12 PubMed

Cold Spring Harb Perspect Biol. 2015 Feb 02;7(2):a016592 PubMed

J Cell Sci. 2002 Jun 1;115(Pt 11):2381-8 PubMed

Science. 2015 Jan 2;347(6217):78-81 PubMed

Nat Commun. 2011;2:243 PubMed

Nature. 2012 Jan 18;481(7381):306-13 PubMed

EMBO J. 2001 Nov 15;20(22):6359-70 PubMed

Genetics. 2006 Nov;174(3):1069-72 PubMed

Genes Dev. 1988 Aug;2(8):929-36 PubMed

Curr Opin Genet Dev. 1998 Aug;8(4):386-91 PubMed

Int J Dev Biol. 2012;56(6-8):479-87 PubMed

Science. 1978 Dec 8;202(4372):1051-5 PubMed

J R Soc Med. 2004 Dec;97(12):560-5 PubMed

Science. 2013 Nov 1;342(6158):632-7 PubMed

Cell. 1987 May 8;49(3):329-36 PubMed

PLoS Biol. 2006 Dec;4(12):e417 PubMed

Theory Biosci. 2013 Jun;132(2):65-71 PubMed

Naturwissenschaften. 2009 Nov;96(11):1247-63 PubMed

Naturwissenschaften. 2004 Jun;91(6):255-76 PubMed

Trends Cell Biol. 2011 Sep;21(9):526-33 PubMed

Curr Biol. 2015 Oct 5;25(19):R941-52 PubMed

Curr Opin Cell Biol. 1995 Dec;7(6):825-34 PubMed

Development. 2005 Feb;132(4):681-7 PubMed

Proc Natl Acad Sci U S A. 1983 Mar;80(5):1387-91 PubMed

J Cell Biol. 2005 Aug 29;170(5):721-32 PubMed

Nat Rev Genet. 2006 Jan;7(1):21-33 PubMed

Neurotox Res. 2015 Feb;27(2):172-97 PubMed

Genes Dev. 2006 Jul 1;20(13):1732-43 PubMed

Dev Cell. 2007 Mar;12(3):467-74 PubMed

Cell. 2012 Jan 20;148(1-2):112-25 PubMed

Cell. 2010 Oct 1;143(1):46-58 PubMed

Nature. 1987 Apr 2-8;326(6112):466-70 PubMed

Mutat Res Rev Mutat Res. 2016 Apr-Jun;768 :53-67 PubMed

Nature. 2004 Apr 22;428(6985):860-4 PubMed

Genetics. 2009 Nov;183(3):757-66 PubMed

Mol Cell Biol. 2011 Jan;31(2):300-16 PubMed

Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5969-73 PubMed

Science. 1982 Apr 9;216(4542):136-44 PubMed

Nat Rev Genet. 2011 Feb;12(2):136-49 PubMed

Nature. 2011 Oct 30;479(7374):534-7 PubMed

Cell Death Dis. 2013 Jan 17;4:e464 PubMed

Nature. 2009 Aug 27;460(7259):1127-31 PubMed

Hum Mol Genet. 2007 Jul 1;16(13):1587-92 PubMed

Nat Commun. 2014 Jun 24;5:4222 PubMed

Science. 1976 Oct 1;194(4260):23-8 PubMed

Nature. 2013 Jan 10;493(7431):231-5 PubMed

Hum Mol Genet. 2007 Jul 1;16(13):1569-77 PubMed

Neuron. 2001 Jan;29(1):15-32 PubMed

Theory Biosci. 2009 Aug;128(3):191-203 PubMed

Nat Cell Biol. 2006 Jul;8(7):677-87 PubMed