Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With CRTC1-MAML2 Fusion Transcript: Report of a Rare Case in a 17-Year-Old Boy and a Review of the Literature
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články, přehledy
PubMed
28637362
DOI
10.1177/1066896917714890
Knihovny.cz E-zdroje
- Klíčová slova
- CRTC1-MAML2, mucoepidermoid carcinoma, palatine tonsil, salivary gland carcinoma, spindle cell,
- MeSH
- DNA vazebné proteiny genetika MeSH
- fúzní onkogenní proteiny genetika MeSH
- jaderné proteiny genetika MeSH
- krční mandle patologie MeSH
- lidé MeSH
- mladiství MeSH
- mukoepidermoidní karcinom genetika patologie MeSH
- tonzilární nádory genetika patologie MeSH
- trans-aktivátory MeSH
- transkripční faktory genetika MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
- Názvy látek
- CRTC1 protein, human MeSH Prohlížeč
- DNA vazebné proteiny MeSH
- fúzní onkogenní proteiny MeSH
- jaderné proteiny MeSH
- MAML2 protein, human MeSH Prohlížeč
- trans-aktivátory MeSH
- transkripční faktory MeSH
Mucoepidermoid carcinoma (MEC) with a predominant spindle cell composition occurring in the palatine tonsil is exceedingly rare. We present a case of a 17-year-old boy with an uncommon spindle cell variant of MEC arising in the palatine tonsil. Histologically, the tumor showed a solid, noncystic architecture and was composed of a predominant population of bland spindle to fusiform cells arranged in organoid nests with interspersed goblet cells and focal areas of ductular structures. Reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization (FISH) revealed the presence of a t(11;19) CRTC1-MAML2 gene fusion in this rare variant of MEC. This is the first case report of a spindle cell MEC of the palatine tonsil, with molecular genetic confirmation. It illustrates the importance of awareness and recognition of this uncommon histological variant of MEC, which will help establish appropriate treatment and prognostication.
Citace poskytuje Crossref.org
Sclerosing mucoepidermoid carcinoma of salivary glands
