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RAS mutation prevalence among patients with metastatic colorectal cancer: a meta-analysis of real-world data

. 2017 Sep ; 11 (9) : 751-760. [epub] 20170727

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/pmid28747067

AIM: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources. MATERIALS & METHODS: Aggregate RAS mutation data were collected from 12 sources in three regions. Each source was analyzed separately; pooled prevalence estimates were then derived from meta-analyses. RESULTS: The pooled RAS mutation prevalence from 4431 tumor samples tested for RAS mutation status was estimated to be 43.6% (95% CI: 38.8-48.5%); ranging from 33.7% (95% CI: 28.4-39.3%) to 54.1% (95% CI: 51.7-56.5%) between sources. CONCLUSION: The RAS mutation prevalence estimates varied among sources. The reasons for this are not clear and highlight the need for further research.

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