Association between taste receptor (TAS) genes and the perception of wine characteristics
Language English Country Great Britain, England Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
28835712
PubMed Central
PMC5569080
DOI
10.1038/s41598-017-08946-3
PII: 10.1038/s41598-017-08946-3
Knihovny.cz E-resources
- MeSH
- Alleles MeSH
- Taste MeSH
- Taste Perception genetics MeSH
- Taste Buds metabolism MeSH
- Adult MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genetic Association Studies * MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Propylthiouracil MeSH
- Wine * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Propylthiouracil MeSH
Several studies have suggested a possible relationship between polymorphic variants of the taste receptors genes and the acceptance, liking and intake of food and beverages. In the last decade investigators have attempted to link the individual ability to taste 6-n-propylthiouracil (PROP) and the sensations, such as astringency and bitterness, elicited by wine or its components, but with contradictory results. We have used the genotype instead of the phenotype (responsiveness to PROP or other tastants), to test the possible relation between genetic variability and the perception of wine characteristic in 528 subjects from Italy and the Czech Republic. We observed several interesting associations, among which the association between several TAS2R38 gene single nucleotide polymorphisms (P = 0.002) and the TAS2R16-rs6466849 polymorphism with wine sourness P = 0.0003). These associations were consistent in both populations, even though the country of origin was an important factor in the two models, thus indicating therefore that genetics alongside cultural factors also play a significant role in the individual liking of wine.
1st Medical Faculty Charles University Prague 12000 Prague Czech Republic
Biomedical Centre Medical School Pilsen Charles University Prague Pilsen Czech Republic
CREA Research Centre for Viticulture Conegliano Italy
Department of Biology Pisa University Pisa Italy
Department of Biomedical Sciences for Health Università degli Studi di Milano Milan Italy
Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany
Sistemi Territoriali S r l 56021 Cascina Loc San Prospero Italy
See more in PubMed
Giacosa A, et al. Mediterranean Way of Drinking and Longevity. Critical reviews in food science and nutrition. 2014 PubMed
Bertelli AA. Wine, research and cardiovascular disease: instructions for use. Atherosclerosis. 2007;195:242–247. doi: 10.1016/j.atherosclerosis.2007.04.006. PubMed DOI
Corder R, et al. Oenology: red wine procyanidins and vascular health. Nature. 2006;444 doi: 10.1038/444566a. PubMed DOI
Giacosa A, et al. Alcohol and wine in relation to cancer and other diseases. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation. 2012;21:103–108. doi: 10.1097/CEJ.0b013e32834761d3. PubMed DOI
Giacosa A, et al. Cancer prevention in Europe: the Mediterranean diet as a protective choice. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation. 2013;22:90–95. doi: 10.1097/CEJ.0b013e328354d2d7. PubMed DOI
Hayes JE, Pickering GJ. Wine Expertise Predicts Taste Phenotype. 2012;63:80–84. PubMed PMC
Ishikawa T, Noble AC. Temporal Perception of Astringency and Sweetness in Red Wine. Food quality and preference. 1995;6:27–33. doi: 10.1016/0950-3293(94)P4209-O. DOI
Pickering, G., Simunkovar, K. & DiBattista, D. In
Smith AK, June H, Noble AC. Effects of viscosity on the bitterness and astringency of grape seed tannin. Food quality and preference. 1996;7:161–166. doi: 10.1016/S0950-3293(96)00028-6. DOI
Soares S, Brandao E, Mateus N, de Freitas V. Sensorial properties of red wine polyphenols: Astringency and bitterness. Critical reviews in food science and nutrition. 2017;57:937–948. doi: 10.1080/10408398.2014.946468. PubMed DOI
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nature genetics. 2002;32:397–401. doi: 10.1038/ng1014. PubMed DOI
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature. 2006;444:288–294. doi: 10.1038/nature05401. PubMed DOI
Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clinical genetics. 2005;67:275–280. doi: 10.1111/j.1399-0004.2004.00361.x. PubMed DOI
Meyerhof W, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical senses. 2010;35:157–170. doi: 10.1093/chemse/bjp092. PubMed DOI
Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiological genomics. 2003;14:73–82. doi: 10.1152/physiolgenomics.00060.2003. PubMed DOI
Soranzo N, et al. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Current biology: CB. 2005;15:1257–1265. doi: 10.1016/j.cub.2005.06.042. PubMed DOI
Adappa ND, et al. Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention. International forum of allergy & rhinology. 2013;3:184–187. doi: 10.1002/alr.21140. PubMed DOI
Adappa ND, et al. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. International forum of allergy & rhinology. 2014;4:3–7. doi: 10.1002/alr.21253. PubMed DOI PMC
Akao H, et al. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Atherosclerosis. 2012;220:456–462. doi: 10.1016/j.atherosclerosis.2011.11.037. PubMed DOI
Campa D, et al. Bitter taste receptor polymorphisms and human aging. PloS one. 2012;7 doi: 10.1371/journal.pone.0045232. PubMed DOI PMC
Campa D, et al. A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer. BMC medical genetics. 2010;11 doi: 10.1186/1471-2350-11-88. PubMed DOI PMC
Carrai M, et al. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin. PloS one. 2011;6 doi: 10.1371/journal.pone.0020464. PubMed DOI PMC
Inoue H, et al. A case study on the association of variation of bitter-taste receptor gene TAS2R38 with the height, weight and energy intake in Japanese female college students. Journal of nutritional science and vitaminology. 2013;59:16–21. doi: 10.3177/jnsv.59.16. PubMed DOI
Kulkarni GV, et al. Association of GLUT2 and TAS1R2 genotypes with risk for dental caries. Caries research. 2013;47:219–225. doi: 10.1159/000345652. PubMed DOI
Lee RJ, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. The Journal of clinical investigation. 2012;122:4145–4159. doi: 10.1172/JCI64240. PubMed DOI PMC
Mfuna Endam L, et al. Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study. International forum of allergy & rhinology. 2014;4:200–206. doi: 10.1002/alr.21275. PubMed DOI
Schembre SM, Cheng I, Wilkens LR, Albright CL. & Marchand le, L. Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk. Nutrition and cancer. 2013;65:982–990. doi: 10.1080/01635581.2013.807934. PubMed DOI PMC
Colares-Bento FC, et al. Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women. Archives of gerontology and geriatrics. 2012;54:e13–18. doi: 10.1016/j.archger.2011.05.019. PubMed DOI
Duffy VB, et al. Vegetable Intake in College-Aged Adults Is Explained by Oral Sensory Phenotypes and TAS2R38 Genotype. Chemosensory perception. 2010;3:137–148. doi: 10.1007/s12078-010-9079-8. PubMed DOI PMC
El-Sohemy A, et al. Nutrigenomics of taste - impact on food preferences and food production. Forum of nutrition. 2007;60:176–182. doi: 10.1159/000107194. PubMed DOI
Gorovic N, et al. Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake. Scandinavian journal of clinical and laboratory investigation. 2011;71:274–279. doi: 10.3109/00365513.2011.559553. PubMed DOI
Hayes JE, Feeney EL, Allen AL. Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food quality and preference. 2013;30:202–216. doi: 10.1016/j.foodqual.2013.05.013. PubMed DOI PMC
Hayes JE, Feeney EL, Nolden AA, McGeary JE. Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31. Chemical senses. 2015;40:437–443. doi: 10.1093/chemse/bjv027. PubMed DOI PMC
Shen Y, Kennedy OB, Methven L. Exploring the effects of genotypical and phenotypical variations in bitter taste sensitivity on perception, liking and intake of brassica vegetables in the UK. Food quality and preference. 2016;50:71–81. doi: 10.1016/j.foodqual.2016.01.005. DOI
Laaksonen O, Ahola J, Sandell M. Explaining and predicting individually experienced liking of berry fractions by the hTAS2R38 taste receptor genotype. Appetite. 2013;61:85–96. doi: 10.1016/j.appet.2012.10.023. PubMed DOI
Duffy VB, et al. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcoholism, clinical and experimental research. 2004;28:1629–1637. doi: 10.1097/01.ALC.0000145789.55183.D4. PubMed DOI PMC
Hinrichs AL, et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. American journal of human genetics. 2006;78:103–111. doi: 10.1086/499253. PubMed DOI PMC
Lanier SA, Hayes JE, Duffy VB. Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiology & behavior. 2005;83:821–831. doi: 10.1016/j.physbeh.2004.10.004. PubMed DOI
Dotson CD, Wallace MR, Bartoshuk LM, Logan HL. Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer. Chemical senses. 2012;37:737–744. doi: 10.1093/chemse/bjs063. PubMed DOI PMC
Wang JC, et al. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcoholism, clinical and experimental research. 2007;31:209–215. doi: 10.1111/j.1530-0277.2006.00297.x. PubMed DOI
Soares S, et al. Different phenolic compounds activate distinct human bitter taste receptors. Journal of agricultural and food chemistry. 2013;61:1525–1533. doi: 10.1021/jf304198k. PubMed DOI
Allen AL, McGeary JE, Hayes JE. Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol. Alcoholism, clinical and experimental research. 2014;38:2550–2560. doi: 10.1111/acer.12527. PubMed DOI PMC
Nolden AA, McGeary JE, Hayes JE. Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes. Physiology & behavior. 2016;156:117–127. doi: 10.1016/j.physbeh.2016.01.017. PubMed DOI PMC
Hayes JE, et al. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chemical senses. 2011;36:311–319. doi: 10.1093/chemse/bjq132. PubMed DOI PMC
De Rosso M, et al. Chemical characterization and enological potential of Raboso varieties by study of secondary grape metabolites. Journal of agricultural and food chemistry. 2010;58:11364–11371. doi: 10.1021/jf102551f. PubMed DOI
Carlson CS, et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American journal of human genetics. 2004;74:106–120. doi: 10.1086/381000. PubMed DOI PMC
Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265. doi: 10.1093/bioinformatics/bth457. PubMed DOI
de Bakker PI, et al. Efficiency and power in genetic association studies. Nature genetics. 2005;37:1217–1223. doi: 10.1038/ng1669. PubMed DOI
Gao X, Starmer J, Martin ER. A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genetic epidemiology. 2008;32:361–369. doi: 10.1002/gepi.20310. PubMed DOI
Boyle AP, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome research. 2012;22:1790–1797. doi: 10.1101/gr.137323.112. PubMed DOI PMC
Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic acids research. 2012;40:D930–934. doi: 10.1093/nar/gkr917. PubMed DOI PMC
GTEX Consortium, G. C. The Genotype-Tissue Expression (GTEx) project. PubMed PMC
