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Prognostic significance of Fuhrman grade and age for cancer-specific and overall survival in patients with papillary renal cell carcinoma: results of an international multi-institutional study on 2189 patients

Borgmann, H
Author Borgmann, H Department of Urology, University Hospital Mainz, Mainz, Germany
Musquera, M
Author Musquera, M Hospital Clínic, University of Barcelona, Barcelona, Spain. mmusquer@clinic.ub.es Department of Urology, Universitat de Barcelona-Hospital Clínic, C/Villarroel, 170, 08036, Barcelona, Spain. mmusquer@clinic.ub.es
Haferkamp, A
Author Haferkamp, A Department of Urology, University Hospital Mainz, Mainz, Germany
Vilaseca, A
Author Vilaseca, A Hospital Clínic, University of Barcelona, Barcelona, Spain
Klatte, T
Author Klatte, T Department of Urology, Medical University of Vienna, Vienna, Austria
Shariat, S F
Author Shariat, S F Department of Urology, Medical University of Vienna, Vienna, Austria
Scavuzzo, A
Author Scavuzzo, A Department of Urology, Instituto Nacional de Cancerologia-INCan, Mexico City, Mexico
Jimenez Rios, M A
Author Jimenez Rios, M A Department of Urology, Instituto Nacional de Cancerologia-INCan, Mexico City, Mexico
Wolff, I
Author Wolff, I Carl-Thiem-Klinikum Cottbus, Cottbus, Germany
Capitanio, U
Author Capitanio, U IRCCS San Raffaele Scientific Institute Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
Dell'Oglio, P
Author Dell'Oglio, P IRCCS San Raffaele Scientific Institute Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
Krabbe, L M
Author Krabbe, L M Department of Urology, University of Muenster Medical Center, Münster, Germany
Herrmann, E
Author Herrmann, E Department of Urology, University of Muenster Medical Center, Münster, Germany
Ecke, T
Author Ecke, T Department of Urology, HELIOS Hospital Bad Saarow, Bad Saarow, Germany
Vergho, D
Author Vergho, D Department of Urology and Paediatric Urology, Julius-Maximilians-University Medical Centre of Würzburg, Würzburg, Germany
Huck, N
Author Huck, N Mannheim Medical Center, Department of Urology, University of Heidelberg, Heidelberg, Germany
Wagener, N
Author Wagener, N Mannheim Medical Center, Department of Urology, University of Heidelberg, Heidelberg, Germany
Pahernik, S
Author Pahernik, S Department of Urology, University Hospital Heidelberg, Heidelberg, Germany
Zastrow, S
Author Zastrow, S Department of Urology, University Hospital Carl Gustav Carus, Dresden, Germany
Wirth, M
Author Wirth, M Department of Urology, University Hospital Carl Gustav Carus, Dresden, Germany
Surcel, C
Author Surcel, C Centre of Urological Surgery, Dialysis and Renal Transplantation, Fundeni Clinical Institute, Bucharest, Romania
Mirvald, C
Author Mirvald, C Centre of Urological Surgery, Dialysis and Renal Transplantation, Fundeni Clinical Institute, Bucharest, Romania
Prochazkova, K
Author Prochazkova, K Department of Urology, Faculty Hospital, Faculty of Medicine, Charles University in Pilsen, Pilsen, Czech Republic
Hutterer, G
Author Hutterer, G Department of Urology, Medical University Graz, Graz, Austria
Zigeuner, R
Author Zigeuner, R Department of Urology, Medical University Graz, Graz, Austria
Cindolo, L
Author Cindolo, L Department of Urology, ASL Abruzzo 2, Chieti, Italy
Hora, M
Author Hora, M Department of Urology, Faculty Hospital, Faculty of Medicine, Charles University in Pilsen, Pilsen, Czech Republic
Stief, C G
Author Stief, C G Department of Urology, Ludwig-Maximilians-University, Campus Grosshadern, Marchionistrasse 15, Munich, 81377, Germany
May, M
Author May, M Department of Urology, Klinikum St. Elisabeth Straubing, Straubing, Germany
Brookman-May, S D
Author Brookman-May, S D Department of Urology, Ludwig-Maximilians-University, Campus Grosshadern, Marchionistrasse 15, Munich, 81377, Germany. sabine.brookman-may@email.de

World journal of urology. 2017 Dec ; 35 (12) : 1891-1897. [epub] 20170823

World J Urol
ISSN 1433-8726 | 0724-4983
Source

Language English Country Germany Media print-electronic

Document type Journal Article, Multicenter Study

Persistent link https://www.medvik.cz/link/pmid28836063

PubMed 28836063
DOI 10.1007/s00345-017-2078-5
PII: 10.1007/s00345-017-2078-5
Knihovny.cz E-resources

Keywords
Grading, Kidney cancer, Mortality, Renal cancer, Renal cell carcinoma, Subtype,
MeSH
Risk Assessment methods MeSH
Kaplan-Meier Estimate MeSH
Carcinoma, Renal Cell * diagnosis mortality pathology surgery MeSH
Organ Sparing Treatments adverse effects methods MeSH
Middle Aged MeSH
Humans MeSH
Mortality MeSH
Kidney Neoplasms * diagnosis mortality pathology surgery MeSH
Nephrectomy * adverse effects methods MeSH
Prognosis MeSH
Proportional Hazards Models MeSH
Retrospective Studies MeSH
Aged MeSH
Neoplasm Staging MeSH
Neoplasm Grading MeSH
Check Tag
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Geographicals
Europe epidemiology MeSH
North America epidemiology MeSH

PURPOSE: Because the prognostic impact of the clinical and pathological features on cancer-specific survival (CSS) and overall survival (OS) in patients with papillary renal cell carcinoma (papRCC) is still controversial, we want to assess the impact of clinicopathological features, including Fuhrman grade and age, on survival in surgically treated papRCC patients in a large multi-institutional series. METHODS: We established a comprehensive multi-institutional database of surgically treated papRCC patients. Histopathological data collected from 2189 patients with papRCC after radical nephrectomy or nephron-sparing surgery were pooled from 18 centres in Europe and North America. OS and CSS probabilities were estimated using the Kaplan-Meier method. Multivariable competing risks analyses were used to assess the impact of Fuhrman grade (FG1-FG4) and age groups (<50 years, 50-75 years, >75 years) on cancer-specific mortality (CSM). RESULTS: CSS and OS rates for patients were 89 and 81% at 3 years, 86 and 75% at 5 years and 78 and 41% at 10 years after surgery, respectively. CSM differed significantly between FG 3 (hazard ratio [HR] 4.22, 95% confidence interval [CI] 2.17-8.22; p < 0.001) and FG 4 (HR 8.93, 95% CI 4.25-18.79; p < 0.001) in comparison to FG 1. CSM was significantly worse in patients aged >75 (HR 2.85, 95% CI 2.06-3.95; p < 0.001) compared to <50 years. CONCLUSIONS: FG is a strong prognostic factor for CSS in papRCC patients. In addition, patients older than 75 have worse CSM than patients younger than 50 years. These findings should be considered for clinical decision making.

Carl Thiem Klinikum Cottbus Cottbus Germany

Centre of Urological Surgery Dialysis and Renal Transplantation Fundeni Clinical Institute Bucharest Romania

Department of Urology and Paediatric Urology Julius Maximilians University Medical Centre of Würzburg Würzburg Germany

Department of Urology ASL Abruzzo 2 Chieti Italy

Department of Urology Faculty Hospital Faculty of Medicine Charles University in Pilsen Pilsen Czech Republic

Department of Urology HELIOS Hospital Bad Saarow Bad Saarow Germany

Department of Urology Instituto Nacional de Cancerologia INCan Mexico City Mexico

Department of Urology Klinikum St Elisabeth Straubing Straubing Germany

Department of Urology Ludwig Maximilians University Campus Grosshadern Marchionistrasse 15 Munich 81377 Germany

Department of Urology Medical University Graz Graz Austria

Department of Urology Medical University of Vienna Vienna Austria

Department of Urology Universitat de Barcelona Hospital Clínic C Villarroel 170 08036 Barcelona Spain