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EQ-5D studies in musculoskeletal and connective tissue diseases in eight Central and Eastern European countries: a systematic literature review and meta-analysis

Zrubka, Zsombor
Author Zrubka, Zsombor Doctoral School of Business and Management, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary Sandoz Hungária Kft, Bartók Béla u. 43-47, 1134, Budapest, Hungary Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary
Rencz, Fanni
Author Rencz, Fanni Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary
Závada, Jakub
Author Závada, Jakub Institute of Rheumatology, Na Slupi 4, Prague, 128 00, Czech Republic
Golicki, Dominik
Author Golicki, Dominik Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, ul. Banacha 1b, 02-097, Warsaw, Poland
Rupel, Valentina Prevolnik
Author Rupel, Valentina Prevolnik Institute for Economic Research, Kardeljeva ploščad 17, 1000, Ljubljana, Slovenia
Simon, Judit
Author Simon, Judit Department of Health Economics, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1 1090, Vienna, Austria
Brodszky, Valentin
Author Brodszky, Valentin Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary
Baji, Petra
Author Baji, Petra Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary
Petrova, Guenka
Author Petrova, Guenka Department of Social Pharmacy and Pharmacoeconomics, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Rotar, Alexandru
Author Rotar, Alexandru Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, 22660, 1100 DD, Amsterdam, The Netherlands
Gulácsi, László
Author Gulácsi, László Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary
Péntek, Márta
Author Péntek, Márta ORCID Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., 1093, Budapest, Hungary. marta.pentek@uni-corvinus.hu Department of Rheumatology, Flór Ferenc County Hospital, Semmelweis tér 1, 2143, Kistarcsa, Hungary. marta.pentek@uni-corvinus.hu

Rheumatology international. 2017 Dec ; 37 (12) : 1957-1977. [epub] 20170828

Rheumatol Int
ISSN 1437-160X | 0172-8172
Source

Language English Country Germany Media print-electronic

Document type Journal Article, Meta-Analysis, Review, Systematic Review

Persistent link https://www.medvik.cz/link/pmid28849432

PubMed 28849432
DOI 10.1007/s00296-017-3800-8
PII: 10.1007/s00296-017-3800-8
Knihovny.cz E-resources

Keywords
Central and Eastern Europe, EQ-5D, Health-related quality of life, Meta-analysis, Musculoskeletal diseases, Patient reported outcomes,
MeSH
Chronic Pain psychology therapy MeSH
Quality of Life * MeSH
Quality-Adjusted Life Years * MeSH
Qualitative Research MeSH
Humans MeSH
Musculoskeletal Diseases psychology therapy MeSH
Connective Tissue Diseases psychology therapy MeSH
Prospective Studies MeSH
Cross-Sectional Studies MeSH
Randomized Controlled Trials as Topic MeSH
Retrospective Studies MeSH
Health Status MeSH
Health Surveys MeSH
Check Tag
Humans MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Meta-Analysis MeSH
Review MeSH
Systematic Review MeSH
Geographicals
Europe MeSH

EQ-5D is becoming the preferred instrument to measure health-state utilities involved in health technology assessment. The objective of this study is to assess the state of EQ-5D research in musculoskeletal disorders in 8 Central and Eastern European countries and to provide a meta-analysis of EQ-5D index scores. Original research articles published in any language between Jan 2000 and Sept 2016 were included, if they reported any EQ-5D outcome from at least two musculoskeletal patients from Austria, Bulgaria, the Czech Republic, Hungary, Poland, Romania, Slovakia, or Slovenia. Risk of bias was assessed with the Cochrane Collaboration's tool. Twenty-nine articles (5992 patients) were included on rheumatoid arthritis (n = 7), osteoporosis (n = 5), chronic pain (n = 5), osteoarthritis (n = 4), ankylosing spondylitis (n = 2), psoriatic arthritis (n = 2), total hip replacement (n = 2), and scleroderma (n = 2). Low back pain was under-represented, while studies in neck pain, systemic lupus erythematosus, gout, and childhood disorders were lacking. EQ-5D index scores were reported in 24 studies, while the version of the instrument and the value-set was not specified in 41% and 46% of the articles, respectively. Meta-analysis was performed on 24 disease states involving 6876 observation points. Intervention effect was reported in 22 subgroups, out of which risk of bias was low in 41%. This review provides recommendations to improve reporting standards of EQ-5D results and highlights potential areas for future research. Coordinated research in conditions with greatest public health impact as well as a development of a regional value-set could provide locally relevant health-state utilities that are transferable among countries within the region.

Department of Experimental and Clinical Pharmacology Medical University of Warsaw ul Banacha 1b 02 097 Warsaw Poland

Department of Health Economics Centre for Public Health Medical University of Vienna Kinderspitalgasse 15 1 1090 Vienna Austria

Department of Health Economics Corvinus University of Budapest Fővám tér 8 1093 Budapest Hungary

Department of Public Health Academic Medical Center University of Amsterdam Amsterdam Public Health Research Institute Meibergdreef 9 22660 1100 DD Amsterdam The Netherlands

Department of Rheumatology Flór Ferenc County Hospital Semmelweis tér 1 2143 Kistarcsa Hungary

Department of Social Pharmacy and Pharmacoeconomics Faculty of Pharmacy Medical University Sofia Bulgaria

Doctoral School of Business and Management Corvinus University of Budapest Fővám tér 8 1093 Budapest Hungary

Institute for Economic Research Kardeljeva ploščad 17 1000 Ljubljana Slovenia

Institute of Rheumatology Na Slupi 4 Prague 128 00 Czech Republic

Sandoz Hungária Kft Bartók Béla u 43 47 1134 Budapest Hungary

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