Patients with IgA nephropathy have altered levels of immunomodulatory C19 steroids. Glucocorticoid therapy with addition of adrenal androgens may be the choice
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
28948828
DOI
10.33549/physiolres.933732
PII: 933732
Knihovny.cz E-zdroje
- MeSH
- androgeny krev farmakologie terapeutické užití MeSH
- dospělí MeSH
- glukokortikoidy farmakologie terapeutické užití MeSH
- IgA nefropatie krev farmakoterapie MeSH
- imunologické faktory krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- nadledviny účinky léků metabolismus MeSH
- peptidy krev MeSH
- prednisolon farmakologie terapeutické užití MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- androgeny MeSH
- C19 peptide MeSH Prohlížeč
- glukokortikoidy MeSH
- imunologické faktory MeSH
- peptidy MeSH
- prednisolon MeSH
Glucocorticoid (GC) therapy is one of the methods of choices for treatment of autoimmune diseases (ADs). In addition, adrenal androgens are known as immunoprotective GC-antagonists. Adrenal steroids preferentially influence the Th1-components over the Th2 ones. We investigated steroid metabolome (using gas chromatography-mass spectrometry) in healthy controls (H), GC-untreated patients with ADs different from IgA nephropathy (U), GC-treated patients with ADs different from IgA nephropathy (T) and in patients with IgA nephropathy (IgAN), which were monitored on the beginning (N0), after one week (N1) and after one month (N2) of prednisolone therapy (60 mg of prednisolone/day/m(2) of body surface). Between-group differences were assessed by one-way ANOVA, while the changes during the therapy were evaluated by repeated measures ANOVA. The ANOVA testing was followed by Duncan's multiple comparisons. IgAN patients and patients with other ADs exhibited lack of adrenal androgens due to attenuated activity of adrenal zona reticularis (ZR). Androgen levels including their 7alpha-, 7beta-, and 16alpha-hydroxy-metabolites were further restrained by GC-therapy. Based on these results and data from the literature, we addressed the question, whether a combination of GCs with delta(5)-steroids or their more stable synthetic derivatives may be optimal for the treatment of antibodies-mediated ADs.
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