Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
29097818
DOI
10.5507/bp.2017.044
Knihovny.cz E-zdroje
- Klíčová slova
- Henoch-Schönlein purpura, atypical bacteria, children, dapsone,
- MeSH
- bakteriální nemoci kůže farmakoterapie MeSH
- Chlamydophila pneumoniae MeSH
- dapson terapeutické užití MeSH
- dítě MeSH
- gastrointestinální nemoci farmakoterapie MeSH
- IgA vaskulitida komplikace MeSH
- infekce bakteriemi rodu Chlamydophila komplikace MeSH
- lidé MeSH
- mladiství MeSH
- Mycoplasma pneumoniae MeSH
- mykoplazmová pneumonie komplikace MeSH
- předškolní dítě MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- dapson MeSH
BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children. METHODS AND RESULTS: Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. In all presented cases, persistent cutaneous manifestations and abdominal pain were resistant to antibiotics and corticosteroids, but resolved during 48 h after the introduction of dapsone. No adverse effects of treatment were observed. CONCLUSION: Dapsone, a sulphone with an anti-inflammatory activity, showed remarkable therapeutic efficacy against rash and gastrointestinal symptoms in children with HSP. Its administration should be considered particularly in persistent cutaneous form of HSP.
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