Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
- Keywords
- Vascular stiffness, adolescent, atherosclerosis, blood pressure, hypertension, obesity, overweight, pulse wave analysis, white coat hypertension,
- MeSH
- Pulse Wave Analysis MeSH
- Arteriosclerosis diagnosis MeSH
- Hypertension diagnosis MeSH
- Ankle blood supply MeSH
- Blood Pressure MeSH
- Humans MeSH
- Adolescent MeSH
- Overweight pathology physiopathology MeSH
- Risk Factors MeSH
- Vascular Stiffness MeSH
- Quality Improvement MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI0. CAVI and CAVI0 were measured in 140 adolescent boys (16.0 ± 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives. Overweight normotensives had significantly lower CAVI and CAVI0 compared to normal-weight normotensives (4.81 ± 0.64 vs. 5.33 ± 0.66, p < .01; 7.10 ± 0.99 vs. 7.81 ± 1.00, p < .01, respectively). CAVI and CAVI0 in overweight essential hypertensives showed no significant difference compared to normal-weight normotensives and were significantly higher compared to overweight normotensives (5.32 ± 0.77 vs. 4.81 ± 0.64, p < .01; 7.77 ± 1.19 vs. 7.10 ± 0.99, p < .01, respectively). CAVI, but not CAVI0, was associated positively with diastolic pressure (0.022 mmHg-1, p = .002) and negatively with pulse pressure (-0.022 mmHg-1, p = .001), and it was significantly higher in overweight white-coat hypertensives compared to overweight normotensives (5.20 ± 0.63 vs. 4.81 ± 0.64, p < .05). The lowering effect of overweight on arterial stiffness indexed by CAVI and CAVI0 in hypertensive adolescents seems to counterbalance the early arteriosclerotic effect of essential hypertension. The increase in CAVI, but not CAVI0, in overweight white-coat hypertensives could be attributable to residual BP dependence of CAVI, which is not present in CAVI0. Under certain conditions, CAVI0 may offer a clinically relevant improved assessment of arterial stiffness superior to CAVI.
b Department of Physiology JFM CU Martin Slovak Republic
c Paediatric Cardiology Martin Slovak Republic
e Clinic of Neonatology JFM CU University Hospital Martin Martin Slovak Republic
f Institute of Scientific Instruments The Czech Academy of Sciences Brno Czech Republic
g International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
References provided by Crossref.org
