Pathological cut-offs of global and regional brain volume loss in multiple sclerosis
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't
- Keywords
- MRI, Multiple sclerosis, brain atrophy, cut-off value, disability,
- MeSH
- Atrophy pathology MeSH
- Corpus Callosum diagnostic imaging pathology MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Magnetic Resonance Imaging standards MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain diagnostic imaging pathology MeSH
- Disease Progression * MeSH
- Multiple Sclerosis diagnosis diagnostic imaging pathology MeSH
- Gray Matter diagnostic imaging pathology MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Thalamus diagnostic imaging pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Volumetric MRI surrogate markers of disease progression are lacking. OBJECTIVE: To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. METHODS: In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study. A total of 11,438 MRI scans performed on the same MRI scanner with the same protocol were analysed. Annualised percentage changes of whole brain, grey matter, thalamus and corpus callosum volumes were estimated. We investigated cut-offs able to discriminate between healthy controls and MS patients. RESULTS: At a predefined specificity of 90%, the annualised percentage change cut-off of corpus callosum volume (-0.57%) was able to distinguish between healthy controls and patients with the highest sensitivity (51% in CIS, 48% in RRMS and 42% in SPMS patients). Lower sensitivities (22%-49%) were found for cut-offs of whole brain, grey matter and thalamic volume loss. Among CIS and RRMS patients, cut-offs were associated with greater accumulation of disability. CONCLUSION: We identified cut-offs of annualised global and regional brain volume loss rates able to discriminate between healthy controls and MS patients.
Department of Health Science University of Genoa Genoa Italy
Department of Medicine Surgery and Neuroscience University of Siena Siena Italy
Department of Statistics and Probability University of Economics Prague Prague Czech Republic
References provided by Crossref.org
Evolution of Brain Volume Loss Rates in Early Stages of Multiple Sclerosis
Establishing pathological cut-offs for lateral ventricular volume expansion rates
