Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article
- Keywords
- SMARCB1 (INI1) deficient carcinoma, gonadal mixed germ cell tumor, sinonasal carcinoma, yolk sac tumor,
- MeSH
- Cell Differentiation MeSH
- Adult MeSH
- SMARCB1 Protein analysis biosynthesis MeSH
- Neoplasms, Germ Cell and Embryonal metabolism MeSH
- Carcinoma metabolism pathology MeSH
- Humans MeSH
- Endodermal Sinus Tumor pathology MeSH
- Biomarkers, Tumor analysis MeSH
- Maxillary Sinus Neoplasms metabolism pathology MeSH
- Ovarian Neoplasms metabolism MeSH
- Testicular Neoplasms metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- SMARCB1 Protein MeSH
- Biomarkers, Tumor MeSH
- SMARCB1 protein, human MeSH Browser
SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. Immunohistochemically, it was diffusely negative for INI1, whereas an expression of yolk sac tumor markers (α-fetoprotein, glypican-3, CDX2) was limited to the yolk sac tumor component. For comparison with the present case, we performed INI1 immunostaining on a series of 11 gonadal germ cell tumors with yolk sac tumor differentiation. All of these cases showed strong and diffuse expression of INI1, in contrast with the present sinonasal tumor. Our findings expand the morphologic spectrum of SMARCB1 (INI1) deficient sinonasal carcinoma. In addition, we show preliminarily that gonadal germ cell tumors with yolk sac tumor differentiation are not SMARCB1/INI1-deficient.
Department of Otorhinolaryngology Head and Neck Surgery Agel Hospital Novy Jicin Czech Republic
Department of Pathology Agel Laboratories a s Novy Jicin Czech Republic
References provided by Crossref.org
