Silica-based nanoparticles are efficient delivery systems for temoporfin
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
29288831
DOI
10.1016/j.pdpdt.2017.12.014
PII: S1572-1000(17)30475-1
Knihovny.cz E-zdroje
- Klíčová slova
- Blood-brain barrier, Drug delivery, Photodynamic therapy, Silica nanoparticles, Temoporfin,
- MeSH
- fotochemoterapie metody MeSH
- fotosenzibilizující látky aplikace a dávkování farmakologie MeSH
- lidé MeSH
- mesoporfyriny aplikace a dávkování farmakologie MeSH
- myši nahé MeSH
- nádorové buněčné linie MeSH
- nanočástice chemie MeSH
- nosiče léků chemie MeSH
- oxid křemičitý chemie MeSH
- polyethylenglykoly chemie MeSH
- transmisní elektronová mikroskopie MeSH
- uvolňování léčiv MeSH
- velikost částic MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fotosenzibilizující látky MeSH
- mesoporfyriny MeSH
- nosiče léků MeSH
- oxid křemičitý MeSH
- polyethylenglykoly MeSH
- temoporfin MeSH Prohlížeč
BACKGROUND: Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site became a new standard in novel anticancer methods Anticancer photodynamic therapy also takes benefit from using nanoparticles by means of increasing targeting efficiency and decreased side effect. With this in mind, the silica-based nanoparticles, as drug delivery systems for the second-generation photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl) chlorin (temoporfin) were developed. METHODS: In order to determine the stability and therapeutic performance of the selected nanomaterials in physiological fluids, their physicochemical properties (i.e. size, polydispersity, zeta potential) were measured by dynamic light scattering technique and the diameter and the morphology of the individual particles were visualized by a transmission electron microscopy. Their efficacy was compared with commercial temoporfin formulation in terms of in vitro phototoxicity in 4T1 (murine mammary carcinoma) and of in vivo anticancer effect in Nu/Nu mice bearing MDA-MB-231 tumors. RESULTS AND CONCLUSIONS: The two types of silica nanoparticles, porous and non-porous and with different surface chemical modification, were involved and critically compared within the study. Their efficacy was successfully demonstrated and was shown to be superior in comparison with commercial temoporfin formulation in terms of in vitro phototoxicity and cellular uptake as well as in terms of in vivo anticancer effect on human breast cancer model. Temoporfin-loaded silica nanoparticles also passed through the blood-brain barrier showing potential for the treatment of brain metastases.
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