Growth/differentiation factor 15 (GDF-15) as new potential serum marker in patients with metastatic colorectal cancer
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
29400662
DOI
10.3233/cbm-170792
PII: CBM170792
Knihovny.cz E-zdroje
- Klíčová slova
- GDF-15, biomarker, colorectal cancer, survival,
- MeSH
- antigen CA-19-9 krev MeSH
- dospělí MeSH
- Kaplanův-Meierův odhad MeSH
- karcinoembryonální antigen krev MeSH
- kolorektální nádory krev mortalita patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- míra přežití MeSH
- nádorové biomarkery krev MeSH
- plocha pod křivkou MeSH
- prognóza MeSH
- ROC křivka MeSH
- růstový diferenciační faktor 15 krev MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigen CA-19-9 MeSH
- GDF15 protein, human MeSH Prohlížeč
- karcinoembryonální antigen MeSH
- nádorové biomarkery MeSH
- růstový diferenciační faktor 15 MeSH
BACKGROUND: GDF-15 is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways. High level GDF-15 in tumor tissues and plasma correlate with an increased risk of recurrence and reduced overall survival. OBJECTIVE: The aim of this study was to screen GDF-15 capacity to detecting metastatic CRC and compare it with standard tumor markers CEA and CA19-9. METHODS: We collected serum samples from 97 patients with metastatic colorectal cancer and 79 samples from healthy controls. Serum levels of GDF-15, CEA and CA19-9 were measured by immunochemically. A Kaplan-Meier curve was applied for analysis of survival rates, and a log-rank was used for univariate analysis. RESULTS: Serum levels of GDF-15 were significantly higher in patients with colorectal cancer compared to healthy controls (p< 0.001). In addition, serum levels of GDF-15 correlated with extent of liver involvement and patients with higher GDF-15 levels had significantly worse outcome (p< 0.0001). CONCLUSIONS: Our results show GDF-15 as an effective biomarker in patients with metastatic colorectal cancer with the same sensitivity as CEA. In addition, GDF-15 levels strongly correlate with extension of liver involvement in contrast with CEA.
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