Gut microbiota: puppeteer of the host juvenile growth
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Bacteria MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Humans MeSH
- Malnutrition complications microbiology prevention & control MeSH
- Growth Disorders etiology metabolism microbiology prevention & control MeSH
- Probiotics therapeutic use MeSH
- Growth MeSH
- Growth Hormone metabolism MeSH
- Mammals microbiology MeSH
- Intestines microbiology MeSH
- Gastrointestinal Microbiome * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Insulin-Like Growth Factor I MeSH
- Growth Hormone MeSH
PURPOSE OF REVIEW: This review focuses on the recent discoveries about the impact of intestinal microbiota on mammalian host juvenile growth. RECENT FINDINGS: Intestinal microbiota is a powerful modulator of many facets of multicellular host's physiology. Recent results from human field studies and animal research have clearly shown that not only the nutrition, but also the intestinal microbiota impacts host postnatal growth kinetics. Absence of microbiome leads to stunted growth in mammalian gnotobiotic models and changes in the composition of the intestinal microbiota can impact the postnatal growth kinetics both positively and negatively under normal nutritional conditions as well as in undernutrition. Strikingly, specific bacterial strains are able to interact with GH/IGF-1 somatotropic axis activity, thus directly impacting host juvenile development. SUMMARY: Intestinal microbiota dictates the pace of host postnatal growth. This newly described role envisages that therapy with specific bacterial strains, together with re-nutritional strategies, might successfully alleviate the long-term sequelae of undernutrition during childhood in humans.
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