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Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 303(5663):1529–31.10.1126/science.1093616
PubMed
DOI
Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 198(3):513–20.10.1084/jem.20030162
PubMed
DOI
PMC
Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, et al. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med (2011) 208(10):1989–2003.10.1084/jem.20101158
PubMed
DOI
PMC
Sisirak V, Faget J, Gobert M, Goutagny N, Vey N, Treilleux I, et al. Impaired IFN-alpha production by plasmacytoid dendritic cells favors regulatory t-cell expansion that may contribute to breast cancer progression. Cancer Res (2012) 72(20):5188–97.10.1158/0008-5472.CAN-11-3468
PubMed
DOI
Conrad C, Gregorio J, Wang YH, Ito T, Meller S, Hanabuchi S, et al. Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3+ T-regulatory cells. Cancer Res (2012) 72(20):5240–9.10.1158/0008-5472.CAN-12-2271
PubMed
DOI
PMC
Ghirelli C, Reyal F, Jeanmougin M, Zollinger R, Sirven P, Michea P, et al. Breast cancer cell-derived GM-CSF licenses regulatory Th2 induction by plasmacytoid predendritic cells in aggressive disease subtypes. Cancer Res (2015) 75(14):2775–87.10.1158/0008-5472.CAN-14-2386
PubMed
DOI
Leifer CA, Medvedev AE. Molecular mechanisms of regulation of toll-like receptor signaling. J Leukoc Biol (2016) 100(5):927–41.10.1189/jlb.2MR0316-117RR
PubMed
DOI
PMC
Bao M, Liu YJ. Regulation of TLR7/9 signaling in plasmacytoid dendritic cells. Protein Cell (2013) 4(1):40–52.10.1007/s13238-012-2104-8
PubMed
DOI
PMC
Swiecki M, Colonna M. The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol (2015) 15(8):471–85.10.1038/nri3865
PubMed
DOI
PMC
Hirsch I, Caux C, Hasan U, Bendriss-Vermare N, Olive D. Impaired toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol (2010) 31(10):391–7.10.1016/j.it.2010.07.004
PubMed
DOI
Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, et al. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits toll-like receptor-induced interferon production. J Exp Med (2006) 203(6):1399–405.10.1084/jem.20052454
PubMed
DOI
PMC
Cao W, Zhang L, Rosen DB, Bover L, Watanabe G, Bao M, et al. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol (2007) 5(10):e248.10.1371/journal.pbio.0050248
PubMed
DOI
PMC
Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 194(12):1823–34.10.1084/jem.194.12.1823
PubMed
DOI
PMC
Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, et al. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med (2009) 206(7):1603–14.10.1084/jem.20090547
PubMed
DOI
PMC
Aouar B, Kovarova D, Letard S, Font-Haro A, Florentin J, Weber J, et al. Dual role of the tyrosine kinase syk in regulation of toll-like receptor signaling in plasmacytoid dendritic cells. PLoS One (2016) 11(6):e0156063.10.1371/journal.pone.0156063
PubMed
DOI
PMC
Hirsch I, Janovec V, Stranska R, Bendriss-Vermare N. Cross talk between inhibitory immunoreceptor tyrosine-based activation motif-signaling and toll-like receptor pathways in macrophages and dendritic cells. Front Immunol (2017) 8:394.10.3389/fimmu.2017.00394
PubMed
DOI
PMC
Martinelli E, Cicala C, Van Ryk D, Goode DJ, Macleod K, Arthos J, et al. HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2007) 104(9):3396–401.10.1073/pnas.0611353104
PubMed
DOI
PMC
Xu Y, Hu Y, Shi B, Zhang X, Wang J, Zhang Z, et al. HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol Immunol (2009) 46(13):2640–6.10.1016/j.molimm.2009.04.031
PubMed
DOI
Florentin J, Aouar B, Dental C, Thumann C, Firaguay G, Gondois-Rey F, et al. HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Blood (2012) 120(23):4544–51.10.1182/blood-2012-02-413286
PubMed
DOI
Healy S, Khan P, Davie JR. Immediate early response genes and cell transformation. Pharmacol Ther (2013) 137(1):64–77.10.1016/j.pharmthera.2012.09.001
PubMed
DOI
Chambard JC, Lefloch R, Pouyssegur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta (2007) 1773(8):1299–310.10.1016/j.bbamcr.2006.11.010
PubMed
DOI
Monje P, Marinissen MJ, Gutkind JS. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol (2003) 23(19):7030–43.10.1128/MCB.23.19.7030-7043.2003
PubMed
DOI
PMC
Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature (1994) 371(6493):171–5.10.1038/371171a0
PubMed
DOI
Kaiser F, Cook D, Papoutsopoulou S, Rajsbaum R, Wu X, Yang HT, et al. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med (2009) 206(9):1863–71.10.1084/jem.20091059
PubMed
DOI
PMC
Chaperot L, Blum A, Manches O, Lui G, Angel J, Molens JP, et al. Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J Immunol (2006) 176(1):248–55.10.4049/jimmunol.176.1.248
PubMed
DOI
Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V, et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 107(34):15181–6.10.1073/pnas.1006539107
PubMed
DOI
PMC
Li J, Du Q, Hu R, Wang Y, Yin X, Yu H, et al. Death receptor 6 is a novel plasmacytoid dendritic cell-specific receptor and modulates type I interferon production. Protein Cell (2016) 7(4):291–4.10.1007/s13238-015-0239-0
PubMed
DOI
PMC
Kim TW, Hong S, Lin Y, Murat E, Joo H, Kim T, et al. Transcriptional repression of IFN regulatory factor 7 by MYC is critical for type I IFN production in human plasmacytoid dendritic cells. J Immunol (2016) 197(8):3348–59.10.4049/jimmunol.1502385
PubMed
DOI
PMC
Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, et al. NFATC3 promotes IRF7 transcriptional activity in plasmacytoid dendritic cells. J Exp Med (2016) 213(11):2383–98.10.1084/jem.20160438
PubMed
DOI
PMC
Pauls E, Shpiro N, Peggie M, Young ER, Sorcek RJ, Tan L, et al. Essential role for IKKbeta in production of type 1 interferons by plasmacytoid dendritic cells. J Biol Chem (2012) 287(23):19216–28.10.1074/jbc.M112.345405
PubMed
DOI
PMC
Rao S, Liu X, Freedman BD, Behrens EM. Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor alpha (TNFalpha) in innate immune cells. J Biol Chem (2013) 288(18):12448–58.10.1074/jbc.M113.454405
PubMed
DOI
PMC
Shiina M, Rehermann B. Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology (2008) 47(2):385–95.10.1002/hep.21996
PubMed
DOI
Gondois-Rey F, Dental C, Halfon P, Baumert TF, Olive D, Hirsch I. Hepatitis C virus is a weak inducer of interferon alpha in plasmacytoid dendritic cells in comparison with influenza and human herpesvirus type-1. PLoS One (2009) 4(2):e4319.10.1371/journal.pone.0004319
PubMed
DOI
PMC
Rock J, Schneider E, Grun JR, Grutzkau A, Kuppers R, Schmitz J, et al. CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2. Eur J Immunol (2007) 37(12):3564–75.10.1002/eji.200737711
PubMed
DOI
Pellerin A, Otero K, Czerkowicz JM, Kerns HM, Shapiro RI, Ranger AM, et al. Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms. EMBO Mol Med (2015) 7(4):464–76.10.15252/emmm.201404719
PubMed
DOI
PMC
Schuster P, Donhauser N, Pritschet K, Ries M, Haupt S, Kittan NA, et al. Co-ordinated regulation of plasmacytoid dendritic cell surface receptors upon stimulation with herpes simplex virus type 1. Immunology (2010) 129(2):234–47.10.1111/j.1365-2567.2009.03176.x
PubMed
DOI
PMC
Varani S, Cederarv M, Feld S, Tammik C, Frascaroli G, Landini MP, et al. Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells. J Immunol (2007) 179(11):7767–76.10.4049/jimmunol.179.11.7767
PubMed
DOI
Sjolin H, Robbins SH, Bessou G, Hidmark A, Tomasello E, Johansson M, et al. DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection. J Immunol (2006) 177(5):2908–16.10.4049/jimmunol.177.8.5748-b
PubMed
DOI
Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, et al. TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun (2017) 8(1):945.10.1038/s41467-017-00101-w
PubMed
DOI
PMC
Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, et al. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol (2012) 189(2):786–92.10.4049/jimmunol.1200887
PubMed
DOI
PMC
Christian SL, Zu D, Licursi M, Komatsu Y, Pongnopparat T, Codner DA, et al. Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. PLoS One (2012) 7(9):e44267.10.1371/journal.pone.0044267
PubMed
DOI
PMC
Chen Y, Chen J, Wang H, Shi J, Wu K, Liu S, et al. HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog (2013) 9(4):e1003248.10.1371/journal.ppat.1003248
PubMed
DOI
PMC
Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, et al. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med (2004) 10(2):187–92.10.1038/nm987
PubMed
DOI
Tomasello E, Pollet E, Vu Manh TP, Uze G, Dalod M. Harnessing mechanistic knowledge on beneficial versus deleterious IFN-I effects to design innovative immunotherapies targeting cytokine activity to specific cell types. Front Immunol (2014) 5:526.10.3389/fimmu.2014.00526
PubMed
DOI
PMC
Centlivre M, Legrand N, Steingrover R, van der Sluis R, Grijsen ML, Bakker M, et al. Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. J Leukoc Biol (2011) 89(5):785–95.10.1189/jlb.0410231
PubMed
DOI
McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol (2010) 10(1):11–23.10.1038/nri2674
PubMed
DOI
PMC
Wursthorn K, Lutgehetmann M, Dandri M, Volz T, Buggisch P, Zollner B, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology (2006) 44(3):675–84.10.1002/hep.21282
PubMed
DOI
Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science (2014) 343(6176):1221–8.10.1126/science.1243462
PubMed
DOI
PMC
Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, et al. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med (2001) 345(20):1452–7.10.1056/NEJMoa011232
PubMed
DOI
Fuertes MB, Kacha AK, Kline J, Woo SR, Kranz DM, Murphy KM, et al. Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med (2011) 208(10):2005–16.10.1084/jem.20101159
PubMed
DOI
PMC
Labidi-Galy SI, Sisirak V, Meeus P, Gobert M, Treilleux I, Bajard A, et al. Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer. Cancer Res (2011) 71(16):5423–34.10.1158/0008-5472.CAN-11-0367
PubMed
DOI
Decalf J, Fernandes S, Longman R, Ahloulay M, Audat F, Lefrerre F, et al. Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J Exp Med (2007) 204(10):2423–37.10.1084/jem.20070814
PubMed
DOI
PMC
Dental C, Florentin J, Aouar B, Gondois-Rey F, Durantel D, Baumert TF, et al. Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells. J Virol (2011) 86(2):1090–6.10.1128/JVI.05444-11
PubMed
DOI
PMC
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 408(3):297–315.10.1042/BJ20070797
PubMed
DOI
PMC
Blight KJ, McKeating JA, Marcotrigiano J, Rice CM. Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J Virol (2003) 77(5):3181–90.10.1128/JVI.77.5.3181-3190.2003
PubMed
DOI
PMC
Delgrange D, Pillez A, Castelain S, Cocquerel L, Rouille Y, Dubuisson J, et al. Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins. J Gen Virol (2007) 88(Pt 9):2495–503.10.1099/vir.0.82872-0
PubMed
DOI
Suchankova A, Hirsch I, Kremar M, Vonka V. Determination of herpes simplex virus type-specific antibodies by solid-phase RIA on helix pomatia lectin-purified antigens. J Infect Dis (1984) 149(6):964–72.10.1093/infdis/149.6.964
PubMed
DOI
Boguszakova L, Hirsch I, Brichacek B, Faltyn J, Fric P, Dvorakova H, et al. Absence of cytomegalovirus, Epstein-Barr virus, and papillomavirus DNA from adenoma and adenocarcinoma of the colon. Acta Virol (1988) 32(4):303–8.
PubMed