Optimal Target Range of Closed-Loop Inspired Oxygen Support in Preterm Infants: A Randomized Cross-Over Study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie, randomizované kontrolované studie
PubMed
29571932
DOI
10.1016/j.jpeds.2018.01.077
PII: S0022-3476(18)30169-0
Knihovny.cz E-zdroje
- Klíčová slova
- automated control, hyperoxemia, hypoxemia, noninvasive respiratory support,
- MeSH
- časové faktory MeSH
- jednotky intenzivní péče o novorozence MeSH
- klinické alarmy statistika a číselné údaje MeSH
- klinické křížové studie MeSH
- kyslík krev MeSH
- lidé MeSH
- neinvazivní ventilace metody MeSH
- novorozenec nedonošený MeSH
- novorozenec MeSH
- oxymetrie metody MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- randomizované kontrolované studie MeSH
- Geografické názvy
- Nizozemsko MeSH
- Názvy látek
- kyslík MeSH
OBJECTIVE: To investigate the effect of different pulse oximetry (SpO2) target range settings during automated fraction of inspired oxygen control (A-FiO2) on time spent within a clinically set SpO2 alarm range in oxygen-dependent infants on noninvasive respiratory support. STUDY DESIGN: Forty-one preterm infants (gestational age [median] 26 weeks, age [median] 21 days) on FiO2 >0.21 receiving noninvasive respiratory support were subjected to A-FiO2 using 3 SpO2 target ranges (86%-94%, 88%-92%, or 89%-91%) in random order for 24 hours each. Before switching to the next target range, SpO2 was manually controlled for 24 hours (washout period). The primary outcome was the time spent within the clinically set alarm limits of 86%-94%. RESULTS: The percent time within the 86%-94% SpO2 alarm range was similar for all 3 A-FiO2 target ranges (74%). Time spent in hyperoxemia was not significantly different between target ranges. However, the time spent in severe hypoxemia (SpO2 <80%) was significantly reduced during the narrowed target ranges of A-FiO2 (88%-92%; 1.9%, 89%-91%; 1.7%) compared with the wide target range (86%-94%; 3.4%, P < .001). There were no differences between the 88%-92% and 89-91% target range. CONCLUSIONS: Narrowing the target range of A-FiO2 to the desired median ±2% is effective in reducing the time spent in hypoxemia, without increasing the risk of hyperoxemia. TRIAL REGISTRATION: www.trialregister.nl: NTR4368.
Department of Neonatology Emma Children's Hospital Academic Medical Center Amsterdam The Netherlands
Faculty of Biomedical Engineering Czech Technical University Prague Kladno Czech Republic
Citace poskytuje Crossref.org
NTR
NTR4368
