Follicular fluid levels of anti-Müllerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Follicular fluid, anti-Müllerian hormone, fertility disorders, insulin-like growth factor 1, leptin,
- MeSH
- Anovulation metabolism MeSH
- Anti-Mullerian Hormone metabolism MeSH
- Biomarkers metabolism MeSH
- Adult MeSH
- Follicular Fluid metabolism MeSH
- Insulin-Like Growth Factor I metabolism MeSH
- Leptin metabolism MeSH
- Humans MeSH
- Young Adult MeSH
- Case-Control Studies MeSH
- Infertility, Female etiology metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Mullerian Hormone MeSH
- Biomarkers MeSH
- IGF1 protein, human MeSH Browser
- Insulin-Like Growth Factor I MeSH
- Leptin MeSH
UNLABELLED: Anti-Müllerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology. ABBREVIATIONS: AMH: anti-Müllerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome.
c Genetics Pilsen Czech Republic
Department of Immunochemistry University Hospital and Faculty of Medicine in Pilsen Czech Republic
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