Follicular fluid levels of anti-Müllerian hormone, insulin-like growth factor 1 and leptin in women with fertility disorders
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Follicular fluid, anti-Müllerian hormone, fertility disorders, insulin-like growth factor 1, leptin,
- MeSH
- anovulace metabolismus MeSH
- antimülleriánský hormon metabolismus MeSH
- biologické markery metabolismus MeSH
- dospělí MeSH
- folikulární tekutina metabolismus MeSH
- insulinu podobný růstový faktor I metabolismus MeSH
- leptin metabolismus MeSH
- lidé MeSH
- mladý dospělý MeSH
- studie případů a kontrol MeSH
- ženská infertilita etiologie metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antimülleriánský hormon MeSH
- biologické markery MeSH
- IGF1 protein, human MeSH Prohlížeč
- insulinu podobný růstový faktor I MeSH
- leptin MeSH
UNLABELLED: Anti-Müllerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology. ABBREVIATIONS: AMH: anti-Müllerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome.
c Genetics Pilsen Czech Republic
Department of Immunochemistry University Hospital and Faculty of Medicine in Pilsen Czech Republic
Citace poskytuje Crossref.org
