Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29779919
DOI
10.1016/j.radonc.2018.05.001
PII: S0167-8140(18)30241-X
Knihovny.cz E-resources
- Keywords
- Dose constraints, European Particle Therapy Network, Organs at risk, Particle therapy,
- MeSH
- Radiotherapy Dosage * MeSH
- Consensus MeSH
- Organs at Risk * radiation effects MeSH
- Humans MeSH
- Brain Neoplasms radiotherapy MeSH
- Radiotherapy Planning, Computer-Assisted methods MeSH
- Proton Therapy adverse effects MeSH
- Heavy Ion Radiotherapy adverse effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
PURPOSE: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study. METHODS: We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science. Moreover, the included articles' reference lists were cross-checked for potential studies that met the inclusion criteria. Consensus was reached among 20 radiation oncology experts in the field of neuro-oncology. RESULTS: For the OARs published in the neuro-oncology literature, we summarized the available literature and recommended dose constraints associated with certain levels of normal tissue complication probability (NTCP) according to the recent ICRU recommendations. For those OARs with lacking or insufficient NTCP data, a proposal for effective and efficient data collection is given. CONCLUSION: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities.
Danish Centre for Particle Therapy Aarhus Denmark
Department of Radiation Oncology Eberhard Carls Universität Tübingen Germany
Department of Radiation Oncology Maastricht The Netherlands
EBG MedAustron GmbH Wiener Neustadt Austria
Haaglanden Medisch Centrum Department of Radiotherapy Leidschendam The Netherlands
Institut Curie Radiation Oncology Department Paris and Proton Center Orsay France
Paul Scherrer Institut Med Center for Proton Therapy Switzerland
Proton Therapy Center Czech Prague Czech Republic
Service de Radiothérapie Oncologique Cliniques universitaires St Luc Brussels Belgium
The Skandion Clinic Uppsala Sweden; Danish Centre for Particle Therapy Aarhus Denmark
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