Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death"
Language English Country United States Media print
Document type Journal Article, Research Support, N.I.H., Extramural, Comment
Grant support
R01 GM053082
NIGMS NIH HHS - United States
R01 NS037402
NINDS NIH HHS - United States
R21 NS096677
NINDS NIH HHS - United States
R21 AI115016
NIAID NIH HHS - United States
R01 GM077875
NIGMS NIH HHS - United States
R01 NS083373
NINDS NIH HHS - United States
PubMed
29930109
PubMed Central
PMC7045345
DOI
10.1126/science.aar6910
PII: 360/6395/eaar6910
Knihovny.cz E-resources
- MeSH
- Apoptosis immunology MeSH
- Aspergillus fumigatus immunology MeSH
- Aspergillosis immunology MeSH
- Cell Death MeSH
- Humans MeSH
- Lung immunology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Research Support, N.I.H., Extramural MeSH
Shlezinger et al (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
Belozersky Institute of Physico Chemical Biology Moscow State University Moscow 119991 Russia
Department of Biology Johns Hopkins University Baltimore MD 21218 USA
Department of Molecular and Cellular Biology University of California Davis CA 95616 USA
Faculty of Science Charles University BIOCEV Vestec Czech Republic
Institute of Microbiology of the Czech Academy of Sciences BIOCEV Vestec Czech Republic
See more in PubMed
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