Toxicity of Diclofenac: Cadmium Binary Mixtures to Algae Desmodesmus subspicatus Using Normalization Method
Language English Country United States Media print-electronic
Document type Journal Article
Grant support
Pollution of the environment and possibilities of elimination of contaminants
FCH-S-18-5331
Regional Materials Science and Technology Centre - Feasibility Program
LO1203
PubMed
29974164
DOI
10.1007/s00128-018-2384-7
PII: 10.1007/s00128-018-2384-7
Knihovny.cz E-resources
- Keywords
- Binary mixtures, Cadmium, Desmodesmus subspicatus, Diclofenac, Normalization method,
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal toxicity MeSH
- Chlorophyta drug effects MeSH
- Diclofenac toxicity MeSH
- Cadmium toxicity MeSH
- Drug Interactions MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Inflammatory Agents, Non-Steroidal MeSH
- Diclofenac MeSH
- Cadmium MeSH
Algal test using chlorococcal algae Desmodesmus subspicatus was used to determine single acute toxicity of either diclofenac or cadmium and to assess acute toxicity of their binary mixtures. The test confirmed significant acute toxicity of both diclofenac and cadmium; diclofenac with acute toxicity ErC50 60.44 ± 0.20 mg/L and cadmium with acute toxicity ErC50 2.14 ± 0.02 mg/L. This study of acute toxicity of binary cadmium-diclofenac mixtures confirmed their negative effects on aquatic producers and it also proved influence of the above substances on acute toxicity of their mixtures. Normalization method was applied to predict acute toxicity of binary mixtures composed of chemicals with significantly different acute toxicities. Normalization method used molar ratio (R) of chemicals in binary mixtures as their composition descriptor.
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