Antibody-mediated rejection after liver transplantation-relevance of C1q and C3d-binding antibodies
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30054978
DOI
10.1111/tan.13354
Knihovny.cz E-resources
- Keywords
- C4d, HLA, antibodies, complement, crossmatch, liver transplantation, rejection,
- MeSH
- Tissue Donors MeSH
- Child MeSH
- Adult MeSH
- Transplantation, Homologous MeSH
- Isoantibodies blood MeSH
- Complement C1q metabolism MeSH
- Complement C3d metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Follow-Up Studies MeSH
- Graft Survival * MeSH
- Prognosis MeSH
- Graft Rejection blood diagnosis immunology pathology MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Histocompatibility Testing methods MeSH
- Liver Transplantation * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Isoantibodies MeSH
- Complement C1q MeSH
- Complement C3d MeSH
The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.
Clinic of Hepatology IKEM Prague Czech Republic
Department of Clinical and Transplantation Pathology IKEM Prague Czech Republic
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