- MeSH
- Anemia, Hemolytic, Autoimmune * diagnosis drug therapy blood pathology MeSH
- Coombs Test MeSH
- Hematologic Tests MeSH
- Hemoglobins analysis drug effects MeSH
- Complement C3d analysis MeSH
- Humans MeSH
- Rituximab administration & dosage MeSH
- Aged MeSH
- Waldenstrom Macroglobulinemia diagnosis complications MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.
- MeSH
- Tissue Donors MeSH
- Child MeSH
- Adult MeSH
- Transplantation, Homologous MeSH
- Isoantibodies blood MeSH
- Complement C1q metabolism MeSH
- Complement C3d metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Follow-Up Studies MeSH
- Graft Survival * MeSH
- Prognosis MeSH
- Graft Rejection blood diagnosis immunology pathology MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Histocompatibility Testing methods MeSH
- Liver Transplantation * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
