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PubMed

Záznam pochází z PubMed

PETC/CT with 18F-Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism

Bossert, I
Autor Bossert, I Unit of Nuclear Medicine, ICS Maugeri, 27100, Pavia, Italy
Chytiris, S
Autor Chytiris, S Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S, University of Pavia, Via S. Maugeri 10, 27100, Pavia, Italy
Hodolic, M
Autor Hodolic, M Nuclear Medicine Research Department, Iason, Graz, Austria Nuclear Medicine Department, Iason, Graz, Austria Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic Nuclear Medicine Department, Policlinico S. Orsola Malpighi, University of Bologna, Bologna, Italy
Croce, L
Autor Croce, L Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S, University of Pavia, Via S. Maugeri 10, 27100, Pavia, Italy
Mansi, L
Autor Mansi, L Inter-Universitary Research Center for Sustainable Development (CIRPS), Naples, Italy
Chiovato, L
Autor Chiovato, L Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S, University of Pavia, Via S. Maugeri 10, 27100, Pavia, Italy. luca.chiovato@icsmaugeri.it
Mariani, G
Autor Mariani, G Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy
Trifirò, G
Autor Trifirò, G Unit of Nuclear Medicine, ICS Maugeri, 27100, Pavia, Italy

Journal of endocrinological investigation. 2019 Apr ; 42 (4) : 419-426. [epub] 20180809

J Endocrinol Invest
ISSN 1720-8386 | 0391-4097
Zdroj

Jazyk angličtina Země Itálie Médium print-electronic

Typ dokumentu časopisecké články

Perzistentní odkaz https://www.medvik.cz/link/pmid30094743

PubMed 30094743
DOI 10.1007/s40618-018-0931-z
PII: 10.1007/s40618-018-0931-z
Knihovny.cz E-zdroje

Klíčová slova
Normocalcemic hyperparathyroidism, PETC/CT with 18F-Choline, Primary hyperparathyroidism,
MeSH
cholin analogy a deriváty MeSH
dospělí MeSH
hyperkalcemie diagnostické zobrazování patologie chirurgie MeSH
hyperparatyreóza diagnostické zobrazování patologie chirurgie MeSH
kohortové studie MeSH
lidé středního věku MeSH
lidé MeSH
nádory příštítného tělíska diagnostické zobrazování patologie chirurgie MeSH
následné studie MeSH
PET/CT metody MeSH
prognóza MeSH
radiofarmaka MeSH
radioisotopová scintigrafie metody MeSH
senioři nad 80 let MeSH
senioři MeSH
ultrasonografie metody MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Názvy látek
cholin MeSH
fluorocholine MeSH Prohlížeč
radiofarmaka MeSH

PURPOSE: Identification of pathologic parathyroid glands in primary hyperparathyroidism, traditionally based on neck ultrasound (US) and/or 99mTc-Sestamibi scintigraphy, can be challenging. PET/CT with 18F-Fluorocholine (18F-FCH) might improve the detection of pathologic parathyroid glands. We aimed at comparing the diagnostic performance of 18F-FCH-PET/CT with that of dual-phase dual-isotope parathyroid scintigraphy and neck US. METHODS: Thirty-four consecutive patients with primary hyperparathyroidism were prospectively enrolled, 7 had normocalcemic hyperparathyroidism, and 27 had classic hypercalcemic hyperparathyroidism. All patients underwent high-resolution neck US, dual-phase dual-isotope 99mTc-Pertechnetate/99mTc-Sestamibi scintigraphy, and 18F-FCH-PET/CT. RESULTS: In the whole patients' group, the detection rates of the abnormal parathyroid gland were 68% for neck US, 71% for 18F-FCH-PET/CT, and only 15% for 99mTc-Sestamibi scintigraphy. The corresponding figures in normocalcemic and hypercalcemic hyperparathyroidism were 57 and 70% for neck US, 70 and 71% for 18F-FCH-PET/CT, and 0 and 18% for 99mTc-Sestamibi scintigraphy, respectively. In the 17 patients in whom the abnormal parathyroid gland was identified, either at surgery or at fine needle aspiration cytology/biochemistry, the correct detection rate was 82% for neck US, 89% for 18F-FCH-PET/CT, and only 17% for 99mTc-Sestamibi scintigraphy. CONCLUSIONS: 18F-FCH-PET/CT can be considered a first-line imaging technique for the identification of pathologic parathyroid glands in patients with normocalcemic and hypercalcemic hyperparathyroidism, even when the parathyroid volume is small.

Faculty of Medicine and Dentistry Palacký University Olomouc Czech Republic

Inter Universitary Research Center for Sustainable Development Naples Italy

Nuclear Medicine Department Iason Graz Austria

Nuclear Medicine Department Policlinico S Orsola Malpighi University of Bologna Bologna Italy

Nuclear Medicine Research Department Iason Graz Austria

Regional Center of Nuclear Medicine University of Pisa Pisa Italy

Unit of Internal Medicine and Endocrinology ICS Maugeri 1 R C C S University of Pavia Via S Maugeri 10 27100 Pavia Italy

Unit of Nuclear Medicine ICS Maugeri 27100 Pavia Italy

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