Assessing the mycotoxicological risk from consumption of complementary foods by infants and young children in Nigeria
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
30118820
DOI
10.1016/j.fct.2018.08.025
PII: S0278-6915(18)30581-7
Knihovny.cz E-resources
- Keywords
- Child health, Complementary foods, Exposure and risk assessment, Infant nutrition, Mycotoxins, Public health,
- MeSH
- Chromatography, Liquid MeSH
- Dietary Exposure * MeSH
- Risk Assessment MeSH
- Infant MeSH
- Food Contamination analysis MeSH
- Humans MeSH
- Limit of Detection MeSH
- Mycotoxins analysis standards toxicity MeSH
- Uncertainty MeSH
- Infant Food analysis MeSH
- Child, Preschool MeSH
- Reference Standards MeSH
- Seasons MeSH
- Tandem Mass Spectrometry MeSH
- Vulnerable Populations MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Nigeria MeSH
- Names of Substances
- Mycotoxins MeSH
This study assessed, for the first time, the mycotoxicological risks from consumption of complementary foods by infants and young children in Nigeria. Molds belonging to Aspergillus aculeatinus, A. flavus, A. luchuensis, A. tubingensis, A. welwitschiae and Geotrichum candidum were recovered from the complementary foods. Twenty-eight major mycotoxins and derivatives, and another 109 microbial metabolites including chloramphenicol (a bacterial metabolite), were quantified in 137 food samples by LC-MS/MS. Aflatoxins and fumonisins co-contaminated 42% of the cereal- and nut-based food samples, at mean concentrations exceeding the EU limits of 0.1 and 200 μg/kg set for processed baby foods by 300 and six times, respectively. Milk contained mainly beauvericin, chloramphenicol and zearalenone. The trichothecenes, T-2 and HT-2 toxins, were quantified only in infant formula and at levels three times above the EU indicative level of 15 μg/kg for baby food. Chronic exposure estimate to carcinogenic aflatoxin was high causing low margin of exposure (MOE). Exposures to other mycotoxins either exceeded the established reference values by several fold or revealed low MOEs, pointing to important health risks in this highly vulnerable population. The observed mycotoxin mixtures may further increase risks of adverse health outcomes of exposure; this warrants urgent advocacy and regulatory interventions.
Department of Microbiology Babcock University Ilishan Remo Ogun State Nigeria
University of Chemistry and Technology Prague Czech Republic
References provided by Crossref.org
Hazard characterisation for significant mycotoxins in food
A Review on Mycotoxins and Microfungi in Spices in the Light of the Last Five Years