Near-fatal Intoxication with the "New" Synthetic Opioid U-47700: The First Reported Case in the Czech Republic
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article
Grant support
GAUK 598217
Charles University
Specific University Research (SVV)
- Keywords
- 3,4- dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide, U47700, clonazolam, forensic science, forensic toxicology, novel benzodiazepine, novel psychoactive substance, synthetic opioid,
- MeSH
- Benzamides adverse effects analysis MeSH
- Benzodiazepines analysis MeSH
- Chromatography, Liquid MeSH
- Citalopram analysis MeSH
- Adult MeSH
- Mass Spectrometry MeSH
- Humans MeSH
- Midazolam analysis MeSH
- Substance Abuse Detection MeSH
- Gas Chromatography-Mass Spectrometry MeSH
- Drug Overdose * MeSH
- Forensic Toxicology MeSH
- Illicit Drugs adverse effects analysis MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Benzamides MeSH
- Benzodiazepines MeSH
- Citalopram MeSH
- Midazolam MeSH
- U-47700 MeSH Browser
- Illicit Drugs MeSH
Recreational use of the potent synthetic opioid 3,4- dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide (U-47700) is rising, accompanied by increasingly frequent cases of serious intoxication. This article reports a case of near-fatal U-47700 intoxication. A man was found unconscious (with drug powder residues). After 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged. Liquid chromatography/high-resolution mass spectrometry (LC/HRMS) or gas chromatography/mass spectrometry (GC/MS) were used to detect and quantify substances in powders, serum and urine. Powders contained U-47700 and two synthetic cannabinoids. Serum and urine were positive for U-47700 (351.0 ng/mL), citalopram (
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