OBJECTIVE: The prevalence of hyperostosis frontalis interna (HFI) was examined in different periods of the Carpathian Basin from 4900 BCE to 17th century AD. The study seeks to evaluate temporal changes in HFI and the possible impact of lifestyle on it. MATERIALS: The studied material consisted of 4668 crania from Hungary and Serbia. METHODS: The crania were analyzed employing macroscopic and endoscopic examination. RESULTS: In historic periods, sex and age played a pivotal role in HFI development. Among predominantly pastoralist populations of the 5th-8th and 10th centuries, prevalence of HFI was considerably higher than in the medieval populations of the 9th-17th centuries. CONCLUSIONS: In addition to age and sex, other factors could be implicated in HFI development. The physiological effects of the pastoralist lifestyle and diet on insulin regulation could explain the increased risk of developing HFI in the 5th-8th and 10th-century populations. SIGNIFICANCE: The study provides the first comprehensive dataset of HFI from different archaeological periods from the Carpathian Basin. It has implications for lifestyle and risk of HFI development in past populations. LIMITATIONS: The archaeological periods are not equally represented. SUGGESTIONS FOR FURTHER RESEARCH: In order to better understand the etiology of HFI, lifestyle factors can be used to elucidate the risk of developing HFI in ancient populations.

Archaeological Heritage Directorate Hungarian National Museum Budapest H 1113 Hungary

Balassa Bálint Museum Esztergom H 2500 Hungary

BioMedical Centrum Ltd Pomáz H 2013 Hungary

Budavári Ingatlanfejlesztő és Üzemeltető Nonprofit Ltd Budapest H 1013 Hungary

Damjanich János Museum Szolnok H 5000 Hungary

Department of Anthropology Hungarian Natural History Museum Budapest H 1083 Hungary

Department of Archaeological Excavations and Artefact Processing Hungarian National Museum Budapest H 1088 Hungary

Department of Archaeology Hungarian National Museum Budapest H 1088 Hungary

Department of Biological Anthropology Institute of Biology Faculty of Science Eötvös Loránd University Budapest H 1117 Hungary

Department of Biological Anthropology Institute of Biology Faculty of Science Eötvös Loránd University Budapest H 1117 Hungary; Department of Archaeometry and Archaeological Methodology Institute of Archaeological Sciences Eötvös Loránd University Budapest H 1088 Hungary

Department of Biological Anthropology University of Szeged Szeged H 6720 Hungary

Department of Early Medieval and Historical Archaeology Institute of Archaeological Sciences Eötvös Loránd University Budapest H 1088 Hungary

Department of Medical Chemistry Molecular Biology and Pathobiochemistry Semmelweis University Budapest H 1094 Hungary

Department of Prehistoric and Migration Period Budapest History Museum Aquincum Museum and Archaeological Park H 1014 H 1031 Budapest Hungary

Department of Sociology Anthropology and Social Work Kansas State University Manhattan KS 66506 USA

Dobó István Castle Museum Eger H 3300 Hungary

Ferenczy Museum Center Szentendre H 2000 Hungary

Hansági Museum Mosonmagyaróvár H 9200 Hungary

Heritage Consulting Ltd Békéscsaba H 5600 Hungary

Institute for History of Medicine and Foreign Languages Charles University Prague 121 08 Czech Republic

Institute of Archaeology Research Centre for the Humanities Hungarian Academy of Sciences Budapest H 1097 Hungary

International Committee of the Red Cross Geneva 1202 Switzerland

Municipal Museum of Subotica Subotica 24000 Serbia

Rippl Rónai Museum Kaposvár H 7400 Hungary

Roska Tamás Doctoral School of Sciences and Technology Faculty of Information Technology and Bionics Pázmány Péter Catholic University Budapest H 1083 Hungary; Neuronal Network and Behavior Research Group Institute of Cognitive Neuroscience and Psychology Research Center for Natural Sciences Hungarian Academy of Sciences Budapest H 1117 Hungary

Salisbury Ltd Budapest H 1016 Hungary

Silk Road Research Group Hungarian Academy of Sciences Eötvös Loránd University Szeged University Budapest Hungary

Wosinsky Mór County Museum Szekszárd H 7100 Hungary

Citace poskytuje Crossref.org