Rare copy number variation in extremely impulsively violent males
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
HHSN268200782096C
NIH HHS - United States
1 X01 HG005274-01
Center for Inherited Disease Research - International
U01 HG004422
NHGRI NIH HHS - United States
CIHR - Canada
U01 HG004438
NHGRI NIH HHS - United States
U01 HG004446
NHGRI NIH HHS - United States
U10 AA008401
NIAAA NIH HHS - United States
P01 CA089392
NCI NIH HHS - United States
R01 DA013423
NIDA NIH HHS - United States
PubMed
30411505
DOI
10.1111/gbb.12536
Knihovny.cz E-resources
- Keywords
- antisocial personality disorder, copy number variation, dissocial personality disorder, genetics, impulsive violence, rare variants,
- MeSH
- Antisocial Personality Disorder genetics MeSH
- Adult MeSH
- Impulsive Behavior * MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Violence * MeSH
- Aged MeSH
- DNA Copy Number Variations * MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
The genetic correlates of extreme impulsive violence are poorly understood, and there have been no studies that have systematically characterized a large group of affected individuals both clinically and genetically. We performed a genome-wide rare copy number variant (CNV) analysis in 281 males from four Czech prisons who met strict clinical criteria for extreme impulsive violence. Inclusion criteria included age ≥ 18 years, an ICD-10 diagnosis of Dissocial Personality Disorder, and the absence of an organic brain disorder. Participants underwent a structured psychiatric assessment to diagnose extreme impulsive violence and then provided a blood sample for genetic analysis. DNA was genotyped and CNVs were identified using Illumina HumanOmni2.5 single-nucleotide polymorphism array platform. Comparing with 10851 external population controls, we identified 828 rare CNVs (frequency ≤ 0.1% among control samples) in 264 participants. The CNVs impacted 754 genes, with 124 genes impacted more than once (2-25 times). Many of these genes are associated with autosomal dominant or X-linked disorders affecting adult behavior, cognition, learning, intelligence, specifically expressed in the brain and relevant to synapses, neurodevelopment, neurodegeneration, obesity and neuropsychiatric phenotypes. Specifically, we identified 31 CNVs of clinical relevance in 31 individuals, 59 likely clinically relevant CNVs in 49 individuals, and 17 recurrent CNVs in 65 individuals. Thus, 123 of 281 (44%) individuals had one to several rare CNVs that were indirectly or directly relevant to impulsive violence. Extreme impulsive violence is genetically heterogeneous and genomic analysis is likely required to identify, further research and specifically treat the causes in affected individuals.
Children's Faculty Hospital Department of Pediatrics and Adolescent Medicine Kosice Slovakia
Department of Molecular Genetics and McLaughlin Centre University of Toronto Toronto Ontario Canada
Institute for Postgraduate Medical Education Prague Czech Republic
Psychology Department National Institute of Mental Health Klecany Czech Republic
Psychology Department University of New York Prague Prague Czech Republic
References provided by Crossref.org
Gut Microbiome in Impulsively Violent Female Convicts