Reactivity of CK7 across the spectrum of renal cell carcinomas with clear cells
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Q39
Charles University Research Fund
FN 00669806
Charles University Research Fund
PubMed
30444288
DOI
10.1111/his.13791
Knihovny.cz E-zdroje
- Klíčová slova
- clear cell renal cell carcinoma, cytokeratin 7, immunohistochemistry, kidney,
- MeSH
- dospělí MeSH
- karcinom z renálních buněk patologie MeSH
- keratin-7 biosyntéza MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery analýza MeSH
- nádory ledvin patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- keratin-7 MeSH
- nádorové biomarkery MeSH
AIMS: Current available data on cytokeratin 7 (CK7) immunostaining pattern in the clear cell renal cell carcinoma (RCC) spectrum is conflicting. The aim of this study was to assess CK7 immunoreactivity within the spectrum of clear cell renal neoplasms, including clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like tumours. METHODS AND RESULTS: We analysed two clones of CK7 and two tumour blocks for a total of 75 cases divided into five distinct groups: (i) low-grade clear cell RCC, (ii) high-grade clear cell RCC, (iii) multicystic renal neoplasm of low malignant potential, (iv) clear cell RCC with cystic changes and (v) clear cell papillary RCC-like tumours. We found the highest CK7 reactivity in low-grade clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like groups, ranging from 60% to 93%. CONCLUSIONS: Our findings show that CK7 immunoreactivity in clear cell RCC is variable, and the extent of staining depends on the grade and architectural growth patterns of the tumours.
Department of Pathology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
Department of Pathology Hospital Tenon Paris Sorbonne University Paris France
Department of Pathology University Hospital Wroclaw Wroclaw Poland
Department of Pathology University of Kansas Medical Center Kansas City Kansas USA
Department of Urology Charles University Prague Faculty of Medicine in Plzeň Pilsen Czech Republic
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