Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
APVV-15-0119
Agentúra na Podporu Výskumu a Vývoja
2/0167/15
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
2/0076/16
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
26230120006
EU Structural Fund ITMS
PubMed
30446908
DOI
10.1007/s11010-018-3463-0
PII: 10.1007/s11010-018-3463-0
Knihovny.cz E-zdroje
- Klíčová slova
- Adiposity, Cardiac connexin-43, Female rats, Melatonin, Omega-3 PUFA, Sucrose diet, Ventricular fibrillation,
- MeSH
- antiarytmika metabolismus farmakologie MeSH
- konexin 43 metabolismus MeSH
- konzumní sacharóza škodlivé účinky MeSH
- krysa rodu Rattus MeSH
- kyseliny mastné omega-3 metabolismus farmakologie MeSH
- melatonin metabolismus farmakologie MeSH
- mikro RNA metabolismus MeSH
- myokard metabolismus MeSH
- obezita chemicky indukované komplikace farmakoterapie metabolismus MeSH
- potkani Wistar MeSH
- proteinkinasa C-delta metabolismus MeSH
- proteinkinasa C-epsilon metabolismus MeSH
- signální transdukce účinky léků MeSH
- srdce účinky léků MeSH
- srdeční arytmie etiologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiarytmika MeSH
- konexin 43 MeSH
- konzumní sacharóza MeSH
- kyseliny mastné omega-3 MeSH
- melatonin MeSH
- mikro RNA MeSH
- MIRN30 microRNA, rat MeSH Prohlížeč
- proteinkinasa C-delta MeSH
- proteinkinasa C-epsilon MeSH
We aimed to explore whether specific high-sucrose intake in older female rats affects myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) signaling, miR-1 and miR-30a expression, and susceptibility of the heart to malignant arrhythmias. Possible benefit of the supplementation with melatonin (40 µg/ml/day) and omega-3 polyunsaturated fatty acids (Omacor, 25 g/kg of rat chow) was examined as well. Results have shown that 8 weeks lasting intake of 30% sucrose solution increased serum cholesterol, triglycerides, body weight, heart weight, and retroperitoneal adipose tissues. It was accompanied by downregulation of cardiac Cx43 and PKCε signaling along with an upregulation of myocardial PKCδ and miR-30a rendering the heart prone to ventricular arrhythmias. There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. The potential impact of these findings may be considerable, and suggests that high-sucrose intake impairs myocardial signaling mediated by Cx43 and PKC contributing to increased susceptibility of the older obese female rat hearts to malignant arrhythmias.
Department of Cellular and Structural Biology UT Health Science Center San Antonio 78229 TX USA
Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic
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