Generalized model of the linear theory of electromigration and its application to electrokinetic chromatography: Theory and software PeakMaster 6-Next Generation
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
15-18424Y
Czech Science Foundation - International
UNCE/SCI/014
Charles University Research Centre - International
GA UK 726716
Charles University Grant Agency - International
GA UK 116217
Charles University Grant Agency - International
PICT-2016-0640
National Scientific and Technical Research Council (Agencia Nacional de Promoción Científica y Tecnológica - ANPCyT) - International
PID ASUT-NFE0004475
National Technological University (Universidad Tecnológica Nacional - UTN) - International
- Keywords
- Capillary zone electrophoresis, Electrokinetic chromatography, Linear theory of electromigration, PeakMaster,
- MeSH
- Models, Chemical MeSH
- Electrophoresis, Capillary methods MeSH
- Electrolytes chemistry MeSH
- Ions chemistry MeSH
- Capillary Electrochromatography methods MeSH
- Linear Models MeSH
- Software * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Electrolytes MeSH
- Ions MeSH
The linear theory of electromigration, including the first-order nonlinear approximation, is generalized to systems with any equilibria fast enough to be considered instantaneous in comparison with the timescale of peak movement. For example, this theory is practically applied in the electrokinetic chromatography (EKC) mode of the CZE. The model enables the calculation of positions and shapes of analyte and system peaks without restricting the number of selectors, the complexation stoichiometry, or simultaneous acid-base equilibria. The latest version of our PeakMaster software, PeakMaster 6-Next Generation, implements the theory in a user-friendly way. It is a free and open-source software that performs all calculations and shows the properties of the background electrolyte and the expected electropherogram within a few seconds. In this paper, we mathematically derive the model, discuss its applicability to EKC systems, and introduce the PeakMaster 6 software.
Centro de Investigación de Métodos Computacionales Santa Fe Argentina
Departamento de Ingeniería en Sistemas de Información FRSF UTN Santa Fe Argentina
Liquid Phase Separations Division Agilent Technologies Deutschland GmbH and Co KG Waldbronn Germany
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