Diseases of the central nervous system (CNS) mean for the human organism a potentially dangerous situation. An investigation of cerebrospinal fluid (CSF) provides important information about a character of CNS impairment in the decision-making diagnostic and therapeutic algorithm. The authors present a brief overview of available cerebrospinal fluid assays, shortened indication criteria, a recommended algorithm of CSF assessment in different suspected diseases, and a view of the external quality system. The whole portfolio of obtainable CSF methodology is further subdivided according to the adequate choice into the first and inevitable basic routine panel, and following complicated analyses of highly specialized character. The basic panel is considered for standard laboratories, the complete specialized assessment should be provided by a super-consulting laboratory.

Central Military Hospital U vojenské nemocnice 1200 Prague Czech Republic

Department of Clinical Chemistry Radomyšlská 336 Strakonice Czech Republic

Department of Laboratory Medicine Golovinova 3 Kadaň Czech Republic

Department of Medical Biophysics and Medical Informatics 3rd Faculty of Medicine Charles University Ruská 87 100 00 Prague 10 Czech Republic

Department of Neurology Karla Čapka 589 Písek Czech Republic

Department of Neurology Medical School 3 Charles University Šrobárova 50 Prague Czech Republic

Department of Neurology Palacký University 1 P Pavlova 2 Olomouc Czech Republic

Department of Neurology Regional Krnov Hospital 1 P Pavlova 11 Krnov Czech Republic

Department of Pediatric Neurology Medical School 2 Charles University 5 Úvalu 84 Prague Czech Republic

Institute of Clinical Chemistry and Laboratory Medicine Medical School 1 Charles University U Nemocnice 2 Prague Czech Republic

Institute of Laboratory Medicine Lab In Bezručova 10 Carlsbad Czech Republic

Pediatric Department Radomyšlská 336 Strakonice Czech Republic

Regional Carlsbad Hospital Americká 2 Carlsbad Czech Republic

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