BACKGROUND: Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing. OBJECTIVE: To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS. METHODS: We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models. DMT exposures and pregnancy outcomes were assessed. RESULTS: Of 9,098 women meeting inclusion criteria, 1,178 (13%) women recorded 1,521 pregnancies. The annualised incidence rate of pregnancy was 0.042 (95% CI 0.040, 0.045). A total of 635 (42%) reported pregnancies were conceived on DMT, increasing from 27% in 2006 to 62% in 2016. The median duration of DMT exposure during pregnancy was 30 days (IQR: 9, 50). There were a higher number of induced abortions on FDA pregnancy class C/D drugs compared with pregnancy class B and no DMT (p = 0.010); but no differences in spontaneous abortions, term or preterm births. CONCLUSIONS: We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.

Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino Avellino Italy

Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases Turkey

Biogen Copenhagen Denmark

Biogen Sydney Australia

Biogen Zug Switzerland

Box Hill Hospital Melbourne Australia

Brain and Mind Centre Sydney Australia

Centre Hospitalier de l'Universite de Montreal Montreal Canada

CISSS Chaudière Appalache Levis Canada

Cliniques Universitaires Saint Luc Brussels Belgium; Université Catholique de Louvain Louvain la Neuve Belgium

CORe Department of Medicine University of Melbourne Melbourne Australia; Department of Neurology Royal Melbourne Hospital Melbourne Australia

CSSS Saint Jérôme Saint Jerome Canada

Department of Basic Medical Sciences Neuroscience and Sense Organs University of Bari Bari Italy

Department of Medicine and Surgery University of Parma Parma Italy

Department of Medicine University of Melbourne Melbourne Australia; Department of Neurology Royal Melbourne Hospital Melbourne Australia

Department of Neurology and Center of Clinical Neuroscience 1st Faculty of Medicine Charles University and General University Hospital Prague Prague Czechia

Department of Neurology ASL3 Genovese Genova Italy; Department of Rehabilitation M L Novarese Hospital Moncrivello Italy

Department of Neuroscience Central Clinical School Monash University Melbourne Australia; Department of Neurology Alfred Hospital Melbourne Australia; Department of Medicine University of Melbourne Melbourne Australia

Dipartimento di Scienze Biomediche e Neuromotorie Università Alma Mater Studiorum Bologna Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy

Division of Neurology Department of Medicine Amiri Hospital Kuwait City Kuwait

Flinders University and Medical Centre Adelaide Australia

Geelong Hospital Geelong Australia

Groene Hart ziekenhuis Gouda the Netherlands

Haydarpasa Numune Training and Research Hospital Istanbul Turkey

Hospital de Galdakao Usansolo Galdakao Spain

Hospital Donostia Spain

Hospital Germans Trias i Pujol Spain

Hospital Universitario La Paz Madrid Spain; Hospital Clínico San Carlos Madrid Spain

Hospital Universitario Virgen Macarena Sevilla Spain

KTU Medical Faculty Farabi Hospital Trabzon Turkey

Liverpool Hospital Sydney Australia

Medical Faculty 19 Mayis University Samsun Turkey

Nemocnice Jihlava Jihlava Czech Republic

Neuro Rive Sud Quebec Canada

Ospedale Civile Azienda Ospedaliero Universitaria Modena Italy

University Newcastle Newcastle Australia; John Hunter Hospital Newcastle Australia

University of Queensland Brisbane Australia; Royal Brisbane and Women's Hospital Brisbane Australia

UOC Neurologia Azienda Sanitaria Unica Regionale Marche AV3 Macerata Italy

Westmead Hospital Sydney Australia

Citace poskytuje Crossref.org

Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women's Health Registry (2020-2024)