Revitalising the rudimentary replacement dentition in the mouse
Language English Country England, Great Britain Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30658984
DOI
10.1242/dev.171363
PII: dev.171363
Knihovny.cz E-resources
- Keywords
- Mammal evolution, Minipig, Mouse molar, Replacement tooth, Sox2, Wnt/β-catenin,
- MeSH
- Swine, Miniature MeSH
- Mice, Transgenic MeSH
- Mice MeSH
- Swine MeSH
- Cell Proliferation physiology MeSH
- Wnt Signaling Pathway physiology MeSH
- SOXB1 Transcription Factors genetics metabolism MeSH
- Tooth Germ cytology embryology MeSH
- Tooth cytology embryology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Sox2 protein, mouse MeSH Browser
- SOXB1 Transcription Factors MeSH
Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition; however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/β-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/β-catenin signalling. Here, we show that stabilising Wnt/β-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth.This article has an associated 'The people behind the papers' interview.
Department of Experimental Biology Faculty of Science Masaryk University 625 00 Brno Czech Republic
Institute of Animal Physiology and Genetics Czech Academy of Sciences 602 00 Brno Czech Republic
References provided by Crossref.org
Plasticity of Dental Cell Types in Development, Regeneration, and Evolution
Role of Cell Death in Cellular Processes During Odontogenesis
Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation
