In vivo testing of a bioresorbable phosphate-based optical fiber
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
MP1401
European Cooperation in Science and Technology - International
15-33459A
Ministerstvo Zdravotnictví Ceské Republiky - International
Interdepartmental Centre "PhotoNext"
Politecnico di Torino - International
- Keywords
- bioresorbable phosphate optical fiber, in vivo testing, pH sensing,
- MeSH
- Phosphates chemistry metabolism MeSH
- Hydrogen-Ion Concentration MeSH
- Rats MeSH
- Optical Fibers * MeSH
- Silicon Dioxide chemistry MeSH
- Rats, Wistar MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Phosphates MeSH
- Silicon Dioxide MeSH
Optical fibers have recently attracted a noticeable interest for biomedical applications because they provide a minimally invasive method for in vivo sensing, imaging techniques, deep-tissue photodynamic therapy or optogenetics. The silica optical fibers are the most commonly used because they offer excellent optical properties, and they are readily available at a reasonable price. The fused silica is a biocompatible material, but it is not bioresorbable so it does not decompose in the body and the fibers must be ex-planted after in vivo use and their fragments can present a considerable risk to the patient when the fiber breaks. In contrast, optical fibers made of phosphate glasses can bring many benefits because such glasses exhibit good transparency in ultraviolet-visible and near-infrared regions, and their solubility in water can be tailored by changing the chemical composition. The bioresorbability and toxicity of phosphate glass-based optical fibers were tested in vivo on male laboratory rats for the first time. The fiber was spliced together with a standard graded-index multi-mode fiber pigtail and an optical probe for in vitro pH measurement was prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method to demonstrate applicability and compatibility of the fiber with common fiber optics.
Biomedical Research Centre University Hospital Hradec Králové Hradec Králové Czech Republic
Consiglio Nazionale delle Ricerche Istituto di Fotonica e Nanotecnologie Trento Italy
Department of Applied Science and Technology and RU INSTM Politecnico di Torino Torino Italy
Department of Solid State Engineering University of Chemistry and Technology Prague Czech Republic
Faculty of Health Studies University of Pardubice Pardubice Czech Republic
Institute of Photonics and Electronics Czech Academy of Sciences Prague Czech Republic
References provided by Crossref.org
Ex-Vivo Measurement of the pH in Aqueous Humor Samples by a Tapered Fiber-Optic Sensor
