A Propensity Score-Matched Cohort Analysis of Outcomes After Stereotactic Radiosurgery in Older versus Younger Patients with Dural Arteriovenous Fistula: An International Multicenter Study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
U54 GM104942
NIGMS NIH HHS - United States
PubMed
30790731
PubMed Central
PMC6698438
DOI
10.1016/j.wneu.2019.01.253
PII: S1878-8750(19)30371-7
Knihovny.cz E-zdroje
- Klíčová slova
- Arteriovenous, Dural, Fistula, Gamma Knife, Older, Radiosurgery, Stereotactic radiosurgery,
- MeSH
- cévní malformace centrálního nervového systému epidemiologie radioterapie MeSH
- dítě MeSH
- dospělí MeSH
- Kaplanův-Meierův odhad MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- radiochirurgie * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sinus cavernosus abnormality účinky záření MeSH
- sinus transversus abnormality účinky záření MeSH
- tendenční skóre MeSH
- věkové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: This study aims to evaluate the outcomes of Gamma Knife stereotactic radiosurgery (SRS) for dural arteriovenous fistulas (dAVFs) in older patients (≥65 years) compared with younger patients (age <65 years). METHODS: Two groups with a total of 96 patients were selected from a database of 133 patients with dAVF from 9 international medical centers with a minimum 6 months follow-up. A 1:2 propensity matching was performed by nearest-neighbor matching criteria based on sex, Borden grade, maximum radiation dose given, and location. The older cohort consisted of 32 patients and the younger cohort consisted of 64 patients. The mean overall follow-up in the combined cohort was 42.4 months (range, 6-210 months). RESULTS: In the older cohort, a transverse sinus location was found to significantly predict dAVF obliteration (P = 0.01). The post-SRS actuarial 3-year and 5-year obliteration rates were 47.7% and 78%, respectively. There were no cases of post-SRS hemorrhage. In the younger cohort, the cavernous sinus location was found to significantly predict obliteration (P = 0.005). The 3-year and 5-year actuarial obliteration rates were 56% and 70%, respectively. Five patients (7.8%) hemorrhaged after SRS. Margin dose ≥25 Gy was predictive of unfavorable outcome. The obliteration rate (P = 0.3), post-SRS hemorrhage rate (P = 0.16), and persistent symptoms after SRS (P = 0.83) were not statistically different between the 2 groups. CONCLUSIONS: SRS achieves obliteration in most older patients with dAVF, with an acceptable rate of complication. There was no increased risk of postradiosurgery complications in the older cohort compared with the younger patients.
Department of Neurological Surgery Na Homolce Hospital Prague Czech Republic
Department of Neurological Surgery University of Manitoba Winnipeg Canada
Department of Neurological Surgery University of Miami Florida USA
Department of Neurological Surgery University of Pennsylvania Philadelphia USA
Department of Neurological Surgery University of Pittsburgh Pittsburg USA
Department of Neurological Surgery University of Puerto Rico San Juan Puerto Rico
Department of Neurological Surgery University of Virginia Virginia USA
Department of Neurological Surgery West Virginia University Morgantown USA
Department of Radiation Oncology Beaumont Health System Michigan USA
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