Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations
Jazyk angličtina Země Itálie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30824153
DOI
10.1016/j.ejmp.2019.01.018
PII: S1120-1797(19)30018-3
Knihovny.cz E-zdroje
- Klíčová slova
- Geant4, Monte Carlo, Proton, RBE, Radiobiological model, Radiotherapy, Survival fraction,
- MeSH
- celková dávka radioterapie MeSH
- lidé MeSH
- metoda Monte Carlo * MeSH
- nádorové buněčné linie MeSH
- protonová terapie * MeSH
- radiobiologie MeSH
- reprodukovatelnost výsledků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
ELI Beamline Project Inst Physics ASCR PALS Center Prague Czech Republic
INFN TO Istituto Nazionale di Fisica Nucleare Sezione di Torino Torino Italy
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